The clinical presentation of acute liver failure and hepatic encephalopathy (HE) in patients with cirrhosis differs significantly. The most serious neurological complication of acute liver failure is the development of devastating brain oedema. Therefore, intracranial pressure monitoring is urgently needed in these patients. Brain oedema is amplified by hypoglycemia, hypoxia and seizures, which are also frequent complications of acute liver failure. Therefore, these parameters must also be monitored. In contrast to acute liver failure in which cerebral dysfunction progresses rapidly, cognitive decline may be clinically undetectable for a long time in cirrhotic patients, until clinically overt symptoms such as psychomotor slowing, disorientation, confusion, extrapyramidal and cerebellar symptoms or a decrease in consciousness occur. Clinically, overt HE is preceded by minimal alterations of cerebral function that can only be detected by neuropsychological or neurophysiological measures, but which nevertheless interfere with the patient's daily living. Rapidly progressing spastic paraparesis (hepatic myelopathy) is a rare complication of cirrhosis. In contrast to HE, it does not respond to blood ammonia lowering therapies but must be considered as an indication for urgent liver transplantation. Cognitive dysfunction has recently been detected in hepatitis C virus (HCV)-infected patients with normal liver function. The patients presented with severe fatigue, cognitive dysfunction and mood disorders. Alterations in brain metabolites, as detected by magnetic resonance spectroscopy, indicated central nervous system alteration in these patients. In contrast to patients with HE, HCV-infected patients did not show motor symptoms or deficits in visual perception, but considerable deficits in attention and concentration ability.

Karin Weissenborn

Martin Bokemeyer

Jochen Krause

Jochen Ennen

Björn Ahl

AIDS

​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​被所有顶级临床医生和研究人员阅读，AIDS 在所有与 AIDS 相关的期刊中影响力最高。 AIDS 每年出版 18 期，保证以权威方式展示重大进展。编辑们本身就是著名的国际专家，他们了解您的工作需求，他们致力于使 AIDS 成为该领域最杰出和最具创新性的期刊。提交的文章将由编辑进行初步审查。有些文章可能会在没有进一步考虑的情况下退回给作者。那些被考虑出版的人将接受编辑的进一步评估和同行评审，以及那些被邀请从审稿人库中这样做的人。

AIDS is the most influential journal among all journals related to AIDS, widely read by top clinicians and researchers. The journal publishes 18 issues annually, aiming to present significant advancements in an authoritative manner. The editorial team consists of internationally recognized experts who understand the needs of researchers and strive to make AIDS the most distinguished and innovative journal in the field. All submitted articles will undergo an initial review by the editors, and some may be returned to authors without further consideration. Articles that are considered for publication will undergo further evaluation by the editors and peer review, conducted by invited reviewers.

《AIDS》是所有与艾滋病相关的期刊中影响力最高的期刊，受到顶级临床医生和研究人员的广泛阅读。该期刊每年出版18期，致力于以权威的方式展示重大进展。编辑团队由国际知名专家组成，他们了解研究者的需求，努力使《AIDS》成为该领域最杰出和最具创新性的期刊。所有提交的文章将经过编辑的初步审查，部分文章可能会在没有进一步考虑的情况下退回给作者。那些被考虑出版的文章将接受编辑的进一步评估和同行评审，评审工作将由邀请的审稿人进行。

Neurological and neuropsychiatric syndromes associated with liver disease

Cognitive dysfunction has recently been detected in hepatitis C virus-infected patients with normal liver function who presented with severe fatigue, cognitive dysfunction and mood disorders, and Alterations in brain metabolites, as detected by magnetic resonance spectroscopy, indicated central nervous system alteration in these patients.

Category	Quartile
医学	2
医学, 免疫学	2
医学, 传染病学	2
医学, 病毒学	2

Neurological and neuropsychiatric syndromes associated with liver disease

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