Abstract Purpose Normal aging can lead to arterial wall stiffening and development of atherosclerosis; however, the effects of overweight conditions can expedite the dysfunction of arterial health. In an earlier study, we identified in a group of abdominal obese pre-menopausal woman that during menses, these women had decreased vascular conductance of the brachial artery during dynamic hand-grip exercise. Endothelial function in abdominal obese (AO) premenopausal women could be associated with being highly sedentary which attenuates dilatory responses to FMD of both upper and lower limb vascular function. We hypothesized that the AO women would exhibit limb-specific differences in artery dilation with reduced dilation in the popliteal artery as compared to the brachial artery. Methods Artery dilatory responses in the brachial and popliteal arteries were assessed using flow-mediated dilation (FMD) in age-matched sedentary controls and AO groups during menses. Results Significant differences were found between groups including % BF, BMI, weight, waist to hip ratio, fasting blood glucose, and oxLDL. A between-group comparison revealed significantly lower percent dilation of the popliteal artery in AO participants compared to controls (p &lt; 0.05) not present in the brachial arteries. Our results also indicate a difference in the time-to-peak (TP) of dilation between the control (33.38 ± 3.232) and AO (62.104 ± 5.813) groups ( p &lt; 0.01). Following FMD correction with shear rate as the covariate, significant differences in FMD between the brachial and popliteal artery were abolished. Conclusion We conclude that young, AO women show a limb-specific difference in dilation of the upper and lower extremities when compared to controls. Thus, reductions in FMD of the popliteal artery could be due to impaired dilation of the downstream resistance vasculature preventing increases in shear within the leg conduit arteries not as significantly in the arms.

Robert M. Restaino

Matthew A. Barlow

Artery Research

《动脉研究》是动脉结构和生理学研究协会 (ARTERY) 的官方期刊，旨在促进有关动脉结构和功能的病理生理学、流行病学、检测、调查和治疗的知识的进步和信息的传播。该杂志发表原创研究文章、评论文章、观点、案例研究、致编辑的信、简短的通信和图片。所有提交的材料都经过严格的同行评审程序。

Artery Research is the official journal of the Artery Society (ARTERY), aimed at advancing and disseminating knowledge related to the pathophysiology, epidemiology, detection, investigation, and treatment of arterial structure and function. The journal publishes original research articles, reviews, viewpoints, case studies, letters to the editor, brief communications, and images. All submitted materials undergo a rigorous peer-review process.

《Artery Research》是动脉结构和生理学研究协会 (ARTERY) 的官方期刊，旨在促进对动脉结构和功能的病理生理学、流行病学、检测、调查和治疗等领域知识的传播与发展。该期刊发表原创研究文章、评论、观点、案例研究、致编辑的信件、简短的通讯以及图片。所有提交的稿件均经过严格的同行评审。

Category	Quartile
医学	4
医学, 外周血管病	4

Limb-Specific Comparison of Flow-Mediated Dilation in Abdominal Obese Pre-menopausal Women

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Journal Info

Category	Quartile
PERIPHERAL VASCULAR DISEASE	4