Abstract Infertility is a global problem being associated with emotional and financial burden. Recent studies have shown contribution of a group of non-coding RNAs, namely circular RNAs (circRNAs) to the etiology of some infertility conditions. CircRNA are transcribed from exons and form a circular RNA molecule, being abundant in eukaryotes. Traditionally classified as non-coding RNA, these transcripts are endogenously produced through either non-canonical back-splicing or linear splicing, typically produced from precursor messenger ribonucleic acid (pre-mRNA). While during the canonical splicing process the 3’ end of the exon is joined to the 5’ end of the succeeding exon to form linear mRNA, during backsplicing, the 3’ end to the 5’ end of the same exon is joined to make a circular molecule. circRNAs are involved in the regulation of several aspects of spermatogenesis. They appear to influence how stem germ cells grow and divide during the sperm production process. Malfunctions in circRNA activity could contribute to male infertility issues stemming from abnormalities in spermatogenesis. In the current review, we highlight the exciting potential of circRNAs as key players in the male fertility.

Emad Babakhanzadeh

Fakhr-Alsadat Hoseininasab

Ali Khodadadian

Majid Nazari

Reza Hajati

Soudeh Ghafouri-Fard

Hereditas

近一个世纪以来，HEREDITAS 发表了原创的前沿研究和评论。作为隆德孟德尔学会的官方期刊，该期刊欢迎来自遗传学和基因组学所有领域的研究。感兴趣的主题包括人类和医学遗传学、动植物遗传学、微生物遗传学、农业和生物信息学。

For nearly a century, Hereditas has published original cutting-edge research and reviews. As the official journal of the Lund Mendel Society, it welcomes research from all areas of genetics and genomics. Topics of interest include human and medical genetics, plant and animal genetics, microbial genetics, agriculture, and bioinformatics.

近一个世纪以来，Hereditas 发表了原创的前沿研究和评论。作为隆德孟德尔学会的官方期刊，该期刊欢迎来自遗传学和基因组学各个领域的研究。感兴趣的主题包括人类和医学遗传学、动植物遗传学、微生物遗传学、农业和生物信息学。

Category	Quartile
生物学	3
生物学, 遗传学	4

Circular RNAs: novel noncoding players in male infertility

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Journal Info

Category	Quartile
GENETICS & HEREDITY	3