Nevus depigmentosus is a congenital disorder characterized by a nonprogressive hypopigmented lesion, which may not be apparent at birth. Thus, it is sometimes difficult to differentiate vitiligo from nevus depigmentosus only by clinical features. We postulated that the histologic changes in lesional and perilesional skin might be different in the 2 conditions. We took biopsies from both lesional and perilesional skin of 100 cases of vitiligo to assess the number of melanocytes, the amount of melanin, dermal inflammatory infiltrate, and other changes. We compared them with 30 cases of nevus depigmentosus. Histologically, lesions of vitiligo showed more basal hypopigmentation and dermal inflammation than perilesional normal skin. With Fontana-Masson staining, 16% of cases of vitiligo showed the presence of melanin. The ratio of pigmented area to epidermal area was 0.06% in vitiligo, whereas 17% in perilesional normal skin and 8.9% in nevus depigmentosus. In NKI/beteb staining, 12% of vitiligo showed the presence of melanocytes, and their average number was 7.68 per square millimeter. The number of melanocytes was also decreased in nevus depigmentosus but not as much as in vitiligo. We also confirmed the presence of melanocytes in 1 of 3 cases of vitiligo by electron microscopy. In conclusion, there are a few melanocytes and melanin in some cases of vitiligo. Therefore, the diagnosis of vitiligo should be made considering these points.

You Chan Kim

Yun Jeon Kim

Hee Young Kang

Seonghyang Sohn

Eun-So Lee

American Journal of Dermatopathology

《美国皮肤病理学杂志》对最新的诊断方法和实验室技术以及对当代社会、法律和伦理问题的见解进行了出色的报道。每期都有关于临床、技术和基础科学进展的评论文章以及富有启发性的详细病例报告。通过《美国皮肤病理学杂志》，您将能够：- 逐步涵盖新的或难以-诊断从最早的组织病理学症状到确认性免疫组织化学和分子研究的疾病。-立即将最新的基础科学发现和临床方法应用于您的工作。-通过同行评审的原创文章，利用您在世界各地的同行和同事的技能和专业知识、“特殊病例报告”、实用指南的覆盖范围和图形演示。-通过期刊的创意论坛来扩展您的视野，讨论有争议的问题并向杰出的研究人员和临床医生学习

The American Journal of Dermatopathology provides in-depth coverage of the latest diagnostic methods and laboratory techniques, while also addressing contemporary social, legal, and ethical issues. Each issue features review articles on clinical, technical, and basic science advancements, as well as detailed case reports. Through the American Journal of Dermatopathology, you will be able to: - Gradually master new or challenging diagnoses, from the earliest histopathological symptoms to confirmatory immunohistochemistry and molecular studies. - Immediately apply the latest basic science discoveries and clinical methods to your work. - Leverage the skills and expertise of your peers and colleagues worldwide through peer-reviewed original articles, as well as a wealth of information from 'special case reports' and practical guidelines. - Expand your horizons through the journal's creative forum, discussing controversial issues and learning from outstanding researchers and clinicians.

《美国皮肤病理学杂志》对最新的诊断方法和实验室技术进行了深入的报道，同时也探讨了当代社会、法律和伦理问题。每期都包含关于临床、技术和基础科学进展的评论文章，以及详细的病例报告。通过《美国皮肤病理学杂志》，您将能够：- 逐步掌握新的或难以诊断的疾病，从最早的组织病理学症状到确认性的免疫组织化学和分子研究。- 立即将最新的基础科学发现和临床方法应用于您的工作。- 通过同行评审的原创文章，利用来自世界各地同行和同事的技能与专业知识，获取“特殊病例报告”和实用指南的丰富信息。- 通过期刊的创意论坛扩展视野，讨论有争议的问题，并向杰出的研究人员和临床医生学习。

Histopathologic Features in Vitiligo

Histologically, lesions of vitiligo showed more basal hypopigmentation and dermal inflammation than perilesional normal skin, and the number of melanocytes was also decreased in nevus depigmentosus but not as much as in Vitiligo, suggesting there are a few melanocytes and melanin in some cases of vitILigo.

Category	Quartile
医学	4
医学, 皮肤病学	4

Histopathologic Features in Vitiligo

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