Five new diketopiperazine alkaloids, brevicompanines D—H (3—7), together with two known analogs, allo-brevicompanine B (1) and fructigenine B (2), were isolated from a deep ocean sediment derived fungus Penicillium sp. Their structures were established by spectroscopic methods including 2D NMR and chiral HPLC analysis. Compounds 4 and 7 inhibited lipopolysaccharide (LPS)-induced nitric oxide production in BV2 microglial cells.

Lin Du

Xinying Yang

Tianjiao Zhu

Fengping Wang

Xiang Xiao

Hyun Park

Qianqun Gu

Chemical and Pharmaceutical Bulletin

CPB 涵盖制药和健康科学领域的各种化学主题，涉及生物活性化合物、天然产物和药物，而 BPB 涉及制药和健康科学领域的广泛生物学主题，包括从基础研究到临床研究的科学研究. FOR DETAILS OF THEIR RESPECTIVE SCOPES, PLEASE REFER TO THE SUBMISSION TOPIC CATEGORIES BELOW.TOPICS: ORGANIC CHEMISTRYIN SILICO SCIENCEINORGANIC CHEMISTRYPHARMACOGNOSYHEALTH STATISTICSFORENSIC SCIENCEBIOCHEMISTRYPHARMACOLOGYPHARMACEUTICAL CARE AND SCIENCEMEDICINAL CHEMISTRYANALYTICAL CHEMISTRYPHYSICAL PHARMACYNATURAL PRODUCT CHEMISTRYTOXICOLOGYENVIRONMENTAL SCIENCEMOLECULAR AND CELLULAR BIOLOGYBIOPHARMACY AND PHARMACOKINETICSPHARMACEUTICAL EDUCATIONCHEMICAL BIOLOGYPHYSICAL CHEMISTRYPHARMACEUTICAL ENGINEERINGEPIDEMIOLOGYHYGIENEREGULATORY SCIENCEIMMUNOLOGY AND MICROBIOLOGYCLINICAL PHARMACYMISCELLANEOUS.

The Chemical and Pharmaceutical Bulletin covers a wide range of chemical topics in the fields of pharmaceuticals and health sciences, including bioactive compounds, natural products, and drugs. The journal also addresses a broad spectrum of biological topics within pharmaceuticals and health sciences, encompassing scientific research from basic studies to clinical investigations. Specific topics include: organic chemistry, in silico science, inorganic chemistry, pharmacognosy, health statistics, forensic science, biochemistry, pharmacology, pharmaceutical care and science, medicinal chemistry, analytical chemistry, physical pharmacy, natural product chemistry, toxicology, environmental science, molecular and cellular biology, biopharmacy and pharmacokinetics, pharmaceutical education, chemical biology, physical chemistry, pharmaceutical engineering, epidemiology, hygiene, regulatory science, immunology and microbiology, clinical pharmacy, and miscellaneous.

《Chemical and Pharmaceutical Bulletin》涵盖了制药和健康科学领域的多种化学主题，涉及生物活性化合物、天然产物和药物等内容。同时，该期刊也关注制药和健康科学领域的广泛生物学主题，包括从基础研究到临床研究的科学探索。具体的主题包括：有机化学、计算科学、无机化学、药用植物学、健康统计学、法医学、生物化学、药理学、药学护理与科学、药物化学、分析化学、物理药理学、天然产物化学、毒理学、环境科学、分子与细胞生物学、生物药剂学与药代动力学、药学教育、化学生物学、物理化学、药学工程、流行病学、卫生学、监管科学、免疫学与微生物学、临床药学及其他相关领域。

Diketopiperazine Alkaloids from a Deep Ocean Sediment Derived Fungus Penicillium sp.

Five new diketopiperazine alkaloids, brevicompanines D-H (3-7), together with two known analogs, allo-brevicompAnine B and fructigenine B (2), were isolated from a deep ocean sediment derived fungus Penicillium sp.

Category	Quartile
医学	4
医学, 药物化学	4
医学, 化学综合	4
医学, 药学	4

Diketopiperazine Alkaloids from a Deep Ocean Sediment Derived Fungus Penicillium sp.

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	3