Autism, which is common in individuals with fragile X syndrome, is often difficult to diagnose. We compared the diagnostic classifications of two measures for autism diagnosis, the ADOS and the ADI-R, in addition to the DSM-IV-TR in 63 males with this syndrome. Overall, 30% of the subjects met criteria for autistic disorder and 30% met criteria for PDD-NOS. The classifications on the ADOS and DSM-IV-TR were most similar, whereas the ADI-R classified subjects as autistic much more frequently. We further investigated the relationship of both FMRP and FMR1 mRNA to symptoms of autism in this cohort and found no significant relationship between the measures of autism and molecular features, including FMRP, FMR1 mRNA, and CGG repeat number.

Susan W. Harris

David Hessl

Beth Goodlin-Jones

Jessica Ferranti

Susan Bacalman

Ingrid Barbato

Flora Tassone

Paul J. Hagerman

Kristin Herman

Randi J. Hagerman

American Journal on Mental Retardation

Autism Profiles of Males With Fragile X Syndrome

脆性X综合征男性患者的自闭症特征

Autism Profiles of Males With Fragile X Syndrome

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