Alzheimer’s disease (AD) is the most common cause of dementia. Epileptic seizures or epileptic activity have been detected in AD, and people with epilepsy have a higher risk of dementia compared to the general population. This suggests that seizures or epileptic activity might often coexist with AD. It is increasingly evident that epileptic activity or seizures are common but often overlooked comorbidities of AD. However, the causal relationship between seizures, epileptic activity and cognitive decline remains uncertain. Experimental data show that amyloid-β (Aβ) and Tau protein can cause neuronal hyperexcitability and has epileptogenic effects. Neural network hyperexcitation regulates the ratio of Aβ isoforms and is linked to the initiation of AD, indicating a shared mechanism. Clinical studies suggest that cognitive impairment accelerates in AD patients with seizures or epileptic activity. This review discusses the relationship between epileptic seizures and AD, the impact of epileptic activity in AD, and potential treatments.

Tsang-Shan Chen

Ming-Chi Lai

Wei-Pin Hong

Chin-Wei Huang

American Journal of Alzheimer s Disease & Other Dementias®

American Journal of Alzheimer's Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer's care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).

The American Journal of Alzheimer's Disease and other Dementias (AJADD) is a journal aimed at professionals on the frontlines of Alzheimer's care, dementia, and clinical depression. It is particularly relevant for physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).

《American Journal of Alzheimer's Disease and other Dementias》是一本面向阿尔茨海默病、痴呆症和临床抑郁症领域专业人士的期刊，特别是那些在阿尔茨海默病护理、痴呆症和临床抑郁症前线工作的医生、护士、精神科医生、管理人员以及其他医疗专业人员，他们负责管理痴呆症患者及其家庭。该期刊是出版伦理委员会（COPE）的成员。

Category	Quartile
医学	4
医学, 临床神经病学	4
医学, 老年医学	4

The Role of Epileptic Activity in Alzheimer’s Disease

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Journal Info

Category	Quartile
GERIATRICS & GERONTOLOGY	3