Objective: To evaluate the effect of Grifola frondosa polysaccharides (GFP) in a rat model of Alzheimer’s disease (AD). Methods: Seventy-five rats were divided into five groups: the normal control group and the AD group treated with or without GFP (100, 200, and 400 mg/kg). Behavioral responses in the open field test and elevated plus maze test were assessed. Additionally, the levels of malondialdehyde and ferric-reducing ability of plasma, and the mRNA expressions of TNF -α, IL-6 , and IL-1β in the hippocampus were measured. Results: Treatment with GFP significantly improved AD-induced behavioral changes in the open field test and elevated plus maze test ( P &lt; 0.05). In addition, the level of malondialdehyde and the mRNA expressions of TNF -α, IL -6, and IL-1β were decreased by GFP treatment in a dose-dependent manner in AD rats ( P &lt; 0.05), while the level of ferric-reducing ability of plasma was significantly increased ( P &lt; 0.05). Conclusions: Oral administration of GFP can reduce inflammation and oxidative stress, as well as improve behavioral responses associated with AD, suggesting its potential use in AD treatment. However, additional studies are needed to elucidate its underlying mechanisms and efficacy.

Samira Behrad

Sina Pourranjbar

Mohammad Pourranjbar

Saeid Abbasi-Maleki

Samira Rostami Mehr

Reza Hossein Gholizadeh Salmani

Nasrollah Moradikor

Asian Pacific Journal of Tropical Biomedicine

该杂志将涵盖生物​​学、细菌学、生物化学、生物技术、细胞生物学、环境生物学、微生物学、医学微生物学、药理学、生理学、病理学、免疫学、病毒学、毒理学、流行病学、疫苗学、血液学、组织病理学、细胞学、遗传学和热带农业。具有临床意义和意义的文章将被优先考虑。

The Asian Pacific Journal of Tropical Biomedicine covers a wide range of fields including biology, bacteriology, biochemistry, biotechnology, cell biology, environmental biology, microbiology, medical microbiology, pharmacology, physiology, pathology, immunology, virology, toxicology, epidemiology, vaccinology, hematology, histopathology, cytology, genetics, and tropical agriculture. Articles with clinical significance and importance will be given priority.

《Asian Pacific Journal of Tropical Biomedicine》涵盖生物学、细菌学、生物化学、生物技术、细胞生物学、环境生物学、微生物学、医学微生物学、药理学、生理学、病理学、免疫学、病毒学、毒理学、流行病学、疫苗学、血液学、组织病理学、细胞学、遗传学和热带农业等领域。具有临床意义和重要性的文章将优先考虑。

Category	Quartile
医学	4
医学, 热带医学	4

Grifola frondosa polysaccharides alleviate Alzheimer's disease in rats

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Journal Info

Category	Quartile
TROPICAL MEDICINE	3