Self-cleaving hammerhead, hairpin, hepatitis delta virus, and glmS ribozymes comprise a family of small catalytic RNA motifs that catalyze the same reversible phosphodiester cleavage reaction, but each motif adopts a unique structure and displays a unique array of biochemical properties. Recent structural, biochemical, and biophysical studies of these self-cleaving RNAs have begun to reveal how active site nucleotides exploit general acid-base catalysis, electrostatic stabilization, substrate destabilization, and positioning and orientation to reduce the free energy barrier to catalysis. Insights into the variety of catalytic strategies available to these model RNA enzymes are likely to have important implications for understanding more complex RNA-catalyzed reactions fundamental to RNA processing and protein synthesis.

Martha J. Fedor

Annual Review of Biophysics

自 1972 年出版的《生物物理学年度回顾》涵盖了生物物理学领域的重大发展，包括大分子结构、功能和动力学、理论和计算生物物理学、细胞的分子生物物理学、物理系统生物学、膜生物物理学、生物技术、纳米技术、和新兴技术。

Published since 1972, the Annual Review of Biophysics covers significant developments in the field of biophysics, including macromolecular structure, function and dynamics, theoretical and computational biophysics, molecular biophysics of cells, physical systems biology, membrane biophysics, biotechnology, nanotechnology, and emerging technologies.

《Annual Review of Biophysics》自1972年出版，涵盖了生物物理学领域的重大进展，包括大分子结构、功能和动力学、理论与计算生物物理学、细胞分子生物物理学、物理系统生物学、膜生物物理学、生物技术、纳米技术以及新兴技术。

Comparative Enzymology and Structural Biology of RNA Self-Cleavage

Self-cleaving hammerhead, hairpin, hepatitis delta virus, and glmS ribozymes comprise a family of small catalytic RNA motifs that catalyze the same reversible phosphodiester cleavage reaction, but each motif adopts a unique structure and displays a unique array of biochemical properties.

Category	Quartile
生物学	1
生物学, 生物物理	1

Comparative Enzymology and Structural Biology of RNA Self-Cleavage

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