Leukotrienes (LTs), both LTB4 and the cysteinyl LTs (CysLTs) LTC4, LTD4 and LTE4, are implicated in a wide variety of inflammatory disorders. These lipid mediators are generated from arachidonic acid via multistep enzymatic reactions through which arachidonic acid is liberated from membrane phospholipids through the action of phospholipase A2. LTB4 and CysLTs exert their biological effects by binding to cognate receptors, which belong to the G protein-coupled receptor superfamily. LTB4 is widely considered to be a potent chemoattractant for most subsets of leukocytes, whereas CysLTs are potent bronchoconstrictors that have effects on airway remodeling. LTs play a central role in the pathogenesis of asthma and many other inflammatory diseases. This review will provide an update on the synthesis, biological function, and relevance of LTs to the pathobiology of allergic diseases, and examine the current and future therapeutic prospects of LT modifiers.

Min Liu

Takehiko Yokomizo

Allergology International

ALLERGOLOGY INTERNATIONAL 是日本过敏学会的官方期刊，发表有关过敏及相关疾病的病因、诊断和治疗的原创论文。论文可能包括控制过敏反应的方法、超敏反应的人类和动物模型以及最广泛意义上的基本和应用临床过敏的其他方面的研究。该杂志旨在鼓励结果的国际交流，并鼓励来自所有国家的作者提交以下三类论文：原创文章、评论文章和致编辑的信。

Allergology International is the official journal of the Japanese Society of Allergology, dedicated to publishing original research papers on the etiology, diagnosis, and treatment of allergies and related diseases. The papers may include methods for controlling allergic reactions, human and animal models of hypersensitivity, and other aspects of basic and applied clinical allergy research in the broadest sense. The journal aims to promote international exchange of research findings and encourages authors from all countries to submit three types of papers: original articles, review articles, and letters to the editor.

《Allergology International》是日本过敏学会的官方期刊，专注于发表关于过敏及相关疾病的原创研究论文。这些论文涵盖了过敏反应的控制方法、超敏反应的人类和动物模型，以及基础和应用临床过敏研究的其他广泛领域。该期刊旨在促进国际间的研究成果交流，并鼓励来自各国的作者提交三类论文：原创研究文章、评论文章和致编辑的信件。

The role of leukotrienes in allergic diseases

This review will provide an update on the synthesis, biological function, and relevance of LTs to the pathobiology of allergic diseases, and examine the current and future therapeutic prospects of LT modifiers.

Category	Quartile
医学	2
医学, 过敏	2
医学, 免疫学	2

The role of leukotrienes in allergic diseases

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