Abstract Recent developments have broadened our perception of SARS-CoV-2, indicating its capability to affect the body systemically beyond its initial recognition as a mere respiratory pathogen. However, the pathways of its widespread are not well understood. Employing a dual-modality approach, we integrated findings from a Murine Hepatitis Virus (MHV) infection model with corroborative clinical data to investigate the pervasive reach of Coronaviruses. The novel presence of viral particles within red blood cells (RBCs) was demonstrated via high-resolution transmission electron microscopy, with computational modeling elucidating a potential heme-mediated viral entry mechanism via Spike protein affinity. Our data affirm viral localization in RBCs, suggesting heme moieties as facilitators for cellular invasion. Exacerbation of MHV pathology upon hemin administration, contrasted with chloroquine-mediated amelioration, underscoring a heme-centric pathway in disease progression. These observations extend the paradigm of Coronavirus pathogenicity to include hemoprotein interactions. This study casts new light on the systemic invasion capabilities of Coronaviruses, linking RBC hemoproteins with viral virulence. The modulation of disease severity through heme-interacting agents heralds a promising avenue for COVID-19 therapeutics. Our findings propose a paradigm shift in the treatment approach, leveraging the virus-heme interplay as a strategic hinge for intervention.

Ayelen Toro

Ana P. Arévalo

Marianoel Pereira-Gómez

Agustina Sabater

Eric A. Zizzi

Paula Perbolianachis

Gaston Pascual

Sofia Lage-Vickers

Jorge L. Pórfido

Ines Achinelli

Rocio Seniuk

Juan Bizzotto

Pablo Sanchis

Alvaro Olivera

Alejandro Leyva

Pilar Moreno

Alicia Costábile

Alvaro Fajardo

Federico Carrión

Martín Fló

Natalia Olivero-Deibe

Fernando Rodriguez

Nicolas Nin

Nicolas Anselmino

Estefania Labanca

Elba Vazquez

Javier Cotignola

Daniel F. Alonso

Maria P. Valacco

Marcelo Marti

Francesco Gentile

Artem Cherkasov

Martina Crispo

Gonzalo Moratorio

Geraldine Gueron

Cell Death and Disease

《细胞死亡与分化》编辑团队为您带来的《细胞死亡与疾病》是转化细胞死亡领域的同行评审在线期刊。它旨在通过其专业（包括癌症、免疫和神经科学）促进实验和内科学的多样化和综合领域。它现在还接受一个新领域的文章：癌症代谢。

Cell Death and Disease is a peer-reviewed online journal launched by the editorial team of Cell Death and Differentiation, focusing on the field of translational cell death. The journal aims to promote diversity and integration in experimental and clinical sciences, covering specialized areas such as cancer, immunology, and neuroscience. Recently, it has also started accepting articles in the new area of cancer metabolism.

《细胞死亡与疾病》是由《细胞死亡与分化》编辑团队推出的同行评审在线期刊，专注于转化细胞死亡领域。期刊旨在促进实验科学与内科学的多样化与综合，涵盖癌症、免疫学和神经科学等专业领域。近期，期刊还开始接受关于癌症代谢的新领域文章。

Blood matters: the hematological signatures of Coronavirus infection

血液的秘密：冠状病毒感染的血液学特征

Category	Quartile
生物学	1
生物学, 细胞生物学	2

Blood matters: the hematological signatures of Coronavirus infection

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Journal Info

Category	Quartile
CELL BIOLOGY	1