Subject-specific cerebrovascular models predict individual unmeasurable vessel haemodynamics using principles of physics, assumed constitutive laws, and measurement-deduced boundary conditions. However, the process of generating these models can be time-consuming, which is a barrier for use in time-sensitive clinical applications. In this work, we developed a semi-automated pipeline to generate anatomically and functionally personalised 0D cerebrovascular models from vasculature geometry and blood flow data. The pipeline extracts the vessel connectivity and geometric parameters from vessel segmentation to automatically generate a bond graph-based (linear and time-dependent) model of subject vasculature. Then, using a neurofuzzy control scheme, the peripheral resistances of the model are calibrated to minimise the discrepancy between measured and predicted blood flow distributions. We validated the pipeline by generating subject-specific models of the Circle of Willis (CoW) for 10 cases and compared haemodynamic predictions against acquired 4D flow MRI data. The results showed a relative error of 0.25 ± 0.66 %  for flow and 13.87 ± 18.24 %  for pulsatility, with a higher error for smaller vessels. We then demonstrated a use case of the model by simulating the blood flow redistribution during vascular occlusion for different CoW geometries. The results highlighted the benefit of a completely connected CoW to redistribute flow. The modular nature and rapid model generation time of this pipeline make it a promising tool for research and clinical use, where the type and structure of data are variable, and computing resources may be limited.

Alireza Sharifzadeh-Kermani

Jiantao Shen

Finbar Argus

Sergio Dempsey

Jethro Wright

Eryn Kwon

Samantha Holdsworth

Gonzalo Maso Talou

Soroush Safaei

Biomechanics and Modeling in Mechanobiology

力学在分子、细胞、组织、器官和有机体水平上调节生物过程。该杂志的一个目标是促进基础和应用研究，整合生物力学和机械生物学相关领域不断扩大的知识库。方法可以是实验的、理论的或计算的；它们可以解决纳米、微观或宏观层面的现象。特别感兴趣的是以下研究：(1) 量化细胞和基质在健康、疾病或损伤中发挥作用的机械环境，(2) 识别和量化机械敏感反应及其机制，(3) 详细说明力学和生物学之间的相互关系生长、重塑、适应和修复等过程，以及 (4) 报告推进治疗和诊断程序的发现。特别鼓励基于固体力学、流体力学或热力学及其相互作用的分析和计算模型；还鼓励报告扩展测量能力的新实验方法和促进分析的新数学方法。

Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. The aim of this journal is to promote both fundamental and applied research, integrating the expanding knowledge base in the fields of biomechanics and mechanobiology. The methods can be experimental, theoretical, or computational, addressing phenomena at the nano, micro, or macro levels. The journal is particularly interested in the following research areas: (1) quantifying the mechanical environment of cells and the extracellular matrix in health, disease, or injury; (2) identifying and quantifying mechanosensitive responses and their mechanisms; (3) detailing the interplay between mechanics and biology in processes such as growth, remodeling, adaptation, and repair; and (4) reporting discoveries that advance therapeutic and diagnostic procedures. Analyses and computational models based on solid mechanics, fluid mechanics, or thermodynamics and their interactions are especially encouraged, as are reports of new experimental methods that enhance measurement capabilities and new mathematical approaches that facilitate analysis.

力学在分子、细胞、组织、器官和有机体水平上调节生物过程。该杂志旨在促进基础和应用研究，整合生物力学和机械生物学相关领域不断扩大的知识库。研究方法可以是实验的、理论的或计算的，涵盖纳米、微观或宏观层面的现象。特别关注以下研究方向：(1) 量化细胞和基质在健康、疾病或损伤中的机械环境；(2) 识别和量化机械敏感反应及其机制；(3) 详细阐述力学与生物学之间的相互关系，包括生长、重塑、适应和修复等过程；(4) 报告推动治疗和诊断程序的发现。特别鼓励基于固体力学、流体力学或热力学及其相互作用的分析和计算模型，同时也鼓励报告扩展测量能力的新实验方法和促进分析的新数学方法。

Category	Quartile
医学	3
医学, 生物物理	2
医学, 工程生物医学	3

Semi-automated pipeline for generating personalised cerebrovascular models

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Journal Info

Category	Quartile
ENGINEERING, BIOMEDICAL	3