Cellular metabolism-related epigenetic modulation plays a pivotal role in the maintenance of cellular homeostasis. Nicotinamide N-methyltransferase (NNMT) serves as a crucial link between cellular metabolism and epigenetics by catalyzing nicotinamide methylation using the universal methyl donor S-adenosyl-L-methionine. This direct connection bridges the methylation-mediated one-carbon metabolism with nicotinamide adenine dinucleotide levels. Numerous studies have revealed tissue-specific differences in NNMT expression and activity, indicating that its varied physiological and pathological roles depend on its distribution. In this review, we provide an overview of the NNMT involvement in various pathological conditions, including cancer, liver disease, obesity, diabetes, brain disease, pulmonary disease, cardiovascular disease, and kidney disease. By synthesizing this information, our article aims to enhance our understanding of the cellular mechanisms underlying NNMT biology related to diverse diseases and lay the molecular groundwork for developing therapeutic strategies for pharmacological interventions.

Jeongwoo Park

Eun Jin Shin

Tae Hyun Kim

Ji Hye Yang

Sung Hwan Ki

Keon Wook Kang

Kyu Min Kim

Archives of Pharmacal Research

ARCHIVES OF PHARMACAL RESEARCH 是韩国药学会的官方期刊，自 1976 年开始出版。ARCHIVES OF PHARMACAL RESEARCH 是一本跨学科期刊，致力于发表药物发现、药物开发、和药物行动，以提供关于药物和候选药物的基本和新颖的信息。

The Archives of Pharmacal Research is the official journal of the Korean Pharmaceutical Society, published since 1976. This interdisciplinary journal focuses on research in drug discovery, drug development, and drug action, aiming to provide fundamental and novel information about drugs and drug candidates.

《Archives of Pharmacal Research》是韩国药学会的官方期刊，自1976年开始出版。该期刊是一份跨学科的学术刊物，专注于药物发现、药物开发和药物作用的研究，旨在提供关于药物及其候选药物的基础和新颖的信息。

Category	Quartile
医学	3
医学, 药学	2
医学, 药物化学	3

Exploring NNMT: from metabolic pathways to therapeutic targets

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	1