Carbamate has been extensively used as a scaffold in the recent era of drug discovery and is a common structural motif of many approved drugs. The carbamate moiety's unique amide-ester hybrid (-O-CO-NH-) feature offers the designing of specific drug-target interactions. Despite the discovery of numerous carbamate derivatives that act on the endocannabinoid system (ECS), the development of clinically effective carbamates remains a challenge. In this review, we highlight the therapeutic potential of carbamate inhibitors of endocannabinoid degrading enzymes as a breakthrough in discovering neurotherapeutic drugs. We discuss the design strategies and medicinal chemistry aspects involved in developing carbamate-based molecular architectures that modulate the endocannabinoid signaling pathway by interfering with fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), and α/β-Hydrolase domain-containing 6 (ABHD6). Additionally, we highlight the dual activity profile of carbamates against FAAH and MAGL, FAAH and cholinesterase, and FAAH and TRPV1 channels. Furthermore, we illustrate the pharmacophores of O-functionalized carbamates and N-cyclic carbamates that are crucial for FAAH and MAGL inhibitory activities, respectively.

Shivani Jaiswal

Senthil Raja Ayyannan

Mini-Reviews in Medicinal Chemistry

MINI-REVIEWS IN MEDICINAL CHEMISTRY 的目的是发表关于药物化学和相关学科近期重要进展的简短评论。MINI-REVIEWS IN MEDICINAL CHEMISTRY 涵盖药物化学的所有领域，包括药物合理设计、合成化学、生物有机化学的发展, 高通量筛选, 组合化学, 药物靶点, 天然产物研究和构效关系研究。MINI-REVIEWS IN MEDICINAL CHEMISTRY 是每一位希望随时了解最新情况的药物和药物化学家的重要期刊。日期与最新和最重要的发展。

The purpose of Mini-Reviews in Medicinal Chemistry is to publish concise reviews on recent significant advances in medicinal chemistry and related disciplines. This journal covers all areas of medicinal chemistry, including rational drug design, synthetic chemistry, developments in bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, natural product research, and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for researchers who wish to stay updated on the latest and most important developments in the field.

《Mini-Reviews in Medicinal Chemistry》旨在发表关于药物化学及相关学科近期重要进展的简短评论。该期刊涵盖药物化学的各个领域，包括药物合理设计、合成化学、生物有机化学的发展、高通量筛选、组合化学、药物靶点、天然产物研究和构效关系研究。《Mini-Reviews in Medicinal Chemistry》是每位希望及时了解药物和药物化学最新进展的研究者的重要期刊。

Category	Quartile
医学	3
医学, 药物化学	3

Promising Inhibitors of Endocannabinoid Degrading Enzymes Sharing a Carbamate Scaffold

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