Upon injury, regenerating skin is metabolically active and requires oxygen for physiological processes related to wound healing. Such processes can be halted in hypoxic conditions common in chronic wounds. Microneedle arrays (MNAs) have been demonstrated to improve therapeutic delivery and wound healing. Recently, few studies have explored the use of oxygen‐releasing MNAs; however, they involve complex manufacturing and handling and fail to eliminate cytotoxic byproducts. To address these challenges, biodegradable and mechanically robust gelatin methacryloyl‐based MNAs are developed that can penetrate the tissue and release oxygen upon exposure to interstitial fluid and wound exudates. The oxygen release rate and biocompatibility of the developed MNAs with different compositions are evaluated and optimized. Interestingly, in vitro studies demonstrate that the optimized compositions can release oxygen at therapeutic levels and significantly increase viability of chronically hypoxic cells to match that of normoxic cells. In vivo studies further confirm that the optimized oxygen‐generating MNAs do not cause any harm or impair healing in a murine model of acute skin injury. Additionally, transcriptomic analysis reveals upregulation of key pathways related to fibroblast motility, lipid metabolism, and a marked reduction in inflammatory signaling, all of which contribute to improved wound healing. The developed strategy can introduce new opportunities in elimination of hypoxia and therefore treatment of chronic wounds.

Lindsay Barnum

Mohamadmahdi Samandari

Yasir Suhail

Steven Toro

Ashkan Novin

Pejman Ghelich

Jacob Quint

Farnooosh Saeedinejad

Manu Komma

None Kshitiz

Ali Tamayol

Advanced NanoBiomed Research

Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science.

 

The scope of Advanced NanoBiomed Research will cover the following key subject areas:

▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging.

▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications.

▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture.

▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs.

▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization.

▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems.

 

with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.

Advanced NanoBiomed Research will provide an Open Access platform for cutting-edge research in nanomedicine, bioengineering, and biomaterials aimed at improving human health. The journal will encompass a wide range of research from increasingly multi- and interdisciplinary fields within traditional areas of biomedicine, bioengineering, and health-related materials science, as well as precision medicine, personalized medicine, drug delivery, and artificial intelligence-driven health science.\n\nThe scope of Advanced NanoBiomed Research will cover the following key subject areas: \n\n▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy, and multimodal imaging.\n\n▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids, and biomimetics (such as artificial cells, exosomes, and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications.\n\n▪ Biointerfaces, such as antimicrobial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering, and 3D cell culture.\n\n▪ Biofabrication, including (bio)inks and technologies aimed at generating functional tissues and organs.\n\n▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches for bone, ligament, muscle, skin, neural, and cardiac tissue engineering, as well as tissue vascularization.\n\n▪ Devices for healthcare applications, disease modeling, and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems.\n\nWith a strong focus on the applications of these fields, from bench to bedside, the journal aims to address the treatment of all diseases and disorders, including infectious diseases, autoimmune diseases, cardiovascular and metabolic diseases, neurological disorders, and cancer; including pharmacology and toxicology studies.

《Advanced NanoBiomed Research》将为前沿的纳米医学、生物工程和生物材料研究提供一个开放获取的平台，旨在改善人类健康。该期刊将涵盖来自生物医学、生物工程和健康相关材料科学等传统领域的多学科和跨学科研究，以及精准医疗、个性化医疗、药物递送和人工智能驱动的健康科学等广泛主题。\n\n《Advanced NanoBiomed Research》的主要研究领域包括：\n\n▪ 纳米医学和纳米技术，应用于药物和基因递送、诊断、治疗诊断、光热和光动力疗法以及多模态成像。\n\n▪ 生物材料，包括水凝胶、二维材料、生物聚合物、复合材料、可生物降解材料、生物混合材料和仿生材料（如人工细胞、外泌体和细胞外囊泡），以及所有用于生物医学应用的有机和无机材料。\n\n▪ 生物界面，如抗微生物表面和涂层，以及用于细胞工程、免疫工程和三维细胞培养的界面。\n\n▪ 生物制造，包括（生物）墨水和技术，旨在生成功能性组织和器官。\n\n▪ 组织工程和再生医学，包括支架和无支架方法，用于骨、韧带、肌肉、皮肤、神经和心脏组织工程及组织血管化。\n\n▪ 用于医疗应用的设备、疾病建模和治疗，如诊断、芯片实验室、器官芯片、生物微机电系统、生物电子设备、可穿戴设备、执行器、软机器人和智能药物递送系统。\n\n该期刊将重点关注这些领域的应用，从实验室到临床，为各种疾病和障碍的治疗提供解决方案，包括传染病、自身免疫病、心血管和代谢疾病、神经系统疾病和癌症；同时包括药理学和毒理学研究。

Biodegradable Oxygen‐Generating Microneedle Patches for Regenerative Medicine Applications

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Journal Info

Category	Quartile
NANOSCIENCE & NANOTECHNOLOGY	2