The endothelium, by releasing nitric oxide (NO), promotes vasodilation and inhibits inflammation, thrombosis, and vascular smooth muscle cell proliferation. These biological actions of NO make it an important component in the endogenous defense against atherosclerosis and its overt clinical complications. Loss of the functional integrity of the endothelium, as seen commonly in the milieu of cardiovascular risk factors, plays an integral role in all stages of atherosclerosis from lesion initiation to plaque rupture. A number of established techniques can assess endothelial function in human vascular beds. The outcome of endothelial testing has profound prognostic implications and is an independent predictor of atherosclerosis disease progression and cardiovascular event rates. The large clinical benefit of statins and angiotensin-converting enzyme inhibitors in patients with atherosclerosis involves favorable effects of endothelial function. Studies of endothelial function represent a prime example of a successful application of insights derived from vascular biology at the bedside.

Dominik Behrendt

Peter Ganz

The American journal of cardiology

THE AMERICAN JOURNAL OF CARDIOLOGY® 每年出版 24 期，是一本独立期刊，专为心血管疾病专家和内科医生设计，在全球拥有心脏病学亚专业。 AJC 是一份独立的、科学的、经过同行评审的原创文章期刊，专注于心血管疾病诊断和治疗的实用、临床方法。 AJC 是心脏病学领域接受出版时间最快的机构之一。专题报道系统性高血压、方法学、药物、起搏、心律失常、预防性心脏病学、充血性心力衰竭、瓣膜性心脏病、先天性心脏病和心肌病。还包括社论、读者的评论和专题讨论会。

The American Journal of Cardiology publishes 24 issues annually and is an independent journal designed for cardiovascular disease specialists and internists, covering all subspecialties of cardiology worldwide. It is a peer-reviewed journal that focuses on original articles emphasizing practical clinical approaches to the diagnosis and treatment of cardiovascular diseases. As one of the fastest journals in the field of cardiology to accept publications, the American Journal of Cardiology features topics such as systemic hypertension, methodology, pharmacology, pacing, arrhythmias, preventive cardiology, congestive heart failure, valvular heart disease, congenital heart disease, and cardiomyopathy. It also includes editorials, reader comments, and special discussions.

《美国心脏病学杂志》（American Journal of Cardiology）每年出版24期，是一本独立的期刊，专为心血管疾病专家和内科医生设计，覆盖全球心脏病学的各个亚专业。该杂志是一份经过同行评审的原创文章期刊，专注于心血管疾病的诊断和治疗，提供实用的临床方法。作为心脏病学领域中接受出版速度最快的期刊之一，《美国心脏病学杂志》涵盖了系统性高血压、方法学、药物、起搏、心律失常、预防性心脏病学、充血性心力衰竭、瓣膜性心脏病、先天性心脏病和心肌病等专题。此外，杂志还包括社论、读者评论和专题讨论。

American Journal of Cardiology

Am J Cardiol

Endothelial function. From vascular biology to clinical applications.

The endothelium, by releasing nitric oxide (NO), promotes vasodilation and inhibits inflammation, thrombosis, and vascular smooth muscle cell proliferation, making it an important component in the endogenous defense against atherosclerosis and its overt clinical complications.

Category	Quartile
医学	3
医学, 心脏和心血管系统	3

Endothelial function. From vascular biology to clinical applications.

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Journal Info

Category	Quartile
CARDIAC & CARDIOVASCULAR SYSTEMS	2