Diabetes mellitus (DM) is a chronic metabolic condition linked to high blood sugar levels. Diabetes causes complications like neuropathy, nephropathy, and retinopathy. Diabetes foot ulcer (DFU) is a significant and serious wound healing issue resulting from uncontrolled DM. The main causes of the development of the DFU are oxidative stress brought on by the NO moiety, release of pro-inflammatory cytokines like tumour necrosis factor (TNF)-α and interleukin (IL-1), cellular dysfunction, and pathogenic microorganisms including staphylococcus and streptococcus species. The two main types of wounds that are prevalent in DFU patients are neuropathic and neuroischemic. If this wound is not properly treated or cared for, a lower limb may have to be amputated. There are several therapy options for DFU, including antibiotics, debridement, dressings, nano formulations, and growth factor preparations like PDGF-BB, to help the wound heal and prevent amputation. Other novel approaches involved the use of nerve taps, microneedle patches, nanotechnology-based formulations and stem cell applications to promote healing. There are possibilities of drug repurposing for the DFU treatment based on targeting specific enzymes. This article summarises the current pathophysiological aspects of DFU and its probable future targets.

Mansi Patel

Vaibhav Patel

Umang Shah

Alkeshkumar Patel

Archives of Physiology and Biochemistry

生理学和生物化学档案：代谢疾病杂志是一本国际同行评审期刊，已重新发行，以满足对代谢疾病的分子、生化和细胞方面的综合出版及其临床和治疗策略日益增长的需求治疗。它发表关于选定主题的完整原创文章、快速论文、评论和小型评论。该杂志的总体目标是传播新方法以提高对主要代谢疾病的理解。范围涵盖与肥胖、2 型糖尿病和代谢综合征等代谢疾病的分子和细胞病理生理学及其相关的所有主题并发症。临床研究被认为是该杂志的组成部分，应与以下主题之一相关：-激素受体和信号转导的失调-基因变异和基因调控过程的贡献-细胞水平的中间代谢受损-肽的分泌和代谢以及介导细胞串扰的其他因素-管理代谢疾病的治疗策略专门针对该领域主题的专题将定期出版。

The Archives of Physiology and Biochemistry is an international peer-reviewed journal focused on the molecular, biochemical, and cellular aspects of metabolic diseases, along with related clinical and therapeutic strategies. This journal aims to meet the growing demand for comprehensive publications on metabolic diseases, publishing complete original research articles, rapid communications, reviews, and mini-reviews. The overall goal of the journal is to disseminate new methods to enhance the understanding of major metabolic diseases. Its scope covers the molecular and cellular pathophysiology of metabolic diseases such as obesity, type 2 diabetes, and metabolic syndrome, as well as related complications. Clinical research is considered an integral part of the journal and should relate to one of the following topics: dysregulation of hormone receptors and signaling pathways, contributions of genetic variations and gene regulatory processes, impaired intermediary metabolism at the cellular level, secretion and metabolism of peptides, and other factors mediating cellular crosstalk. Additionally, special topics specifically addressing themes in this field will be published regularly.

《Archives of Physiology and Biochemistry》是一本国际同行评审的期刊，专注于代谢疾病的分子、生化和细胞方面的研究，以及相关的临床和治疗策略。该期刊旨在满足对代谢疾病研究日益增长的需求，发表完整的原创研究文章、快速论文、评论和小型评论。期刊的总体目标是传播新方法，以加深对主要代谢疾病的理解。其研究范围涵盖肥胖、2型糖尿病和代谢综合征等代谢疾病的分子和细胞病理生理学，以及相关的并发症。临床研究被视为该期刊的重要组成部分，需与以下主题之一相关：激素受体和信号转导的失调、基因变异和基因调控过程的贡献、细胞水平的中间代谢受损、肽的分泌和代谢，以及其他介导细胞串扰的因素。此外，针对该领域主题的专题将定期出版。

Molecular pathology and therapeutics of the diabetic foot ulcer; comprehensive reviews

The current pathophysiological aspects of DFU and its probable future targets are summarized, including possibilities of drug repurposing for the DFU treatment based on targeting specific enzymes.

Category	Quartile
医学	4
医学, 内分泌学与代谢	4
医学, 生理学	4

Molecular pathology and therapeutics of the diabetic foot ulcer; comprehensive reviews

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