The purpose of this article is to provide a comprehensive review of metabolomics studies for psychosis, as a means of biomarker discovery. Manuscripts were selected for review if they involved discovery of metabolites using high‐throughput analysis in human subjects and were published in the last decade. The metabolites identified were searched in Human Metabolome Data Base (HMDB) for a link to psychosis. Metabolites associated with psychosis based on evidence in HMBD were then searched using PubMed to explore the availability of further evidence. Almost all of the studies which underwent full review involved patients with schizophrenia. Ten biomarkers were identified. Six of them were reported in two or more independent metabolomics studies: N‐acetyl aspartate , lactate , tryptophan , kynurenine , glutamate , and creatine . Four additional metabolites were encountered in a single metabolomics study but had significant evidence (two supporting articles or more) for a link to psychosis based on PubMed: linoleic acid, D‐serine , glutathione , and 3‐hydroxybutyrate . The pathways affected are discussed as they may be relevant to the pathophysiology of psychosis, and specifically of schizophrenia, as well as, constitute new drug targets for treatment of related conditions. Based on the biomarkers identified, early diagnosis of schizophrenia and/or monitoring may be possible.

Christopher Li

Aviva Wang

Chloe Wang

Janani Ramamurthy

Edlyn Zhang

Elena Guadagno

Yannis Trakadis

American Journal of Medical Genetics Part B Neuropsychiatric Genetics

美国医学遗传学杂志 (AJMG) 的 B 部分神经精神遗传学为神经和精神疾病遗传机制的实验和临床研究提供了一个论坛。它是对精神疾病和其他神经系统疾病的遗传性质进行新的遗传学研究的资源，以分子、细胞或行为水平为特征。 《神经精神遗传学》每年出版八次。

The American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics serves as a forum for experimental and clinical research on the genetic mechanisms of neuropsychiatric disorders. It is a resource for new genetic studies on the hereditary nature of mental illnesses and other neurological conditions, characterized by molecular, cellular, or behavioral levels. The journal is published eight times a year.

《American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics》是美国医学遗传学杂志的B部分，专注于神经和精神疾病的遗传机制。该期刊为实验和临床研究提供了一个重要的论坛，旨在探讨精神疾病及其他神经系统疾病的遗传特性，涵盖分子、细胞和行为层面的新遗传学研究。该期刊每年出版八期。

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Metabolomics in patients with psychosis: A systematic review

A comprehensive review of metabolomics studies for psychosis, as a means of biomarker discovery, identified ten biomarkers which may be relevant to the pathophysiology of psychosis, and specifically of schizophrenia.

Category	Quartile
医学	3
医学, 遗传学	3
医学, 精神病学	3

Metabolomics in patients with psychosis: A systematic review

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