Cutaneous malignant melanoma is one of the few major cancers that continue to exhibit a positive rate of increase in the developed world. A wealth of epidemiological data has undisputedly implicated ultraviolet radiation (UVR) from sunlight and artificial sources as the major risk factor for melanomagenesis. However, the molecular mechanisms of this cause-and-effect relationship remain murky and understudied. Recent efforts on multiple fronts have brought unprecedented expansion of our knowledge base on this subject and it is now clear that melanoma is caused by a complex interaction between genetic predisposition and environmental exposure, primarily to UVR. Here we provide an overview of the effects of the macroenvironment (UVR) on the skin microenvironment and melanocyte-specific intrinsic (mostly genetic) landscape, which conspire to produce one of the deadliest malignancies.

Xuan Mo

Sarah Preston

M Raza Zaidi

Advances in cancer research

癌症研究进展 (ACR) 涵盖了一段非凡的发现时期，其中包括生物学革命的开始。癌症研究进展 (ACR) 涵盖了一段非凡的发现时期，其中包括生物学革命的开始。第一本 ACR 卷出版于 WATSON 和 CRICK 报道生物学中心法则 DNA 双螺旋的那一年。在前 100 卷中，发现了一些帮助塑造这场革命的人的许多贡献，他们在癌症研究中取得了许多显着的发现，并由此发展而来。

Advances in Cancer Research covers significant advancements in the field of cancer research, marking the beginning of a biological revolution. The first volume was published in the same year that Watson and Crick reported the double helix structure of DNA. In the first 100 volumes, numerous contributions from scientists who shaped this revolution led to significant discoveries in cancer research, driving the development of the field.

《Advances in Cancer Research》涵盖了癌症研究领域的重大进展，标志着生物学革命的开端。第一卷的出版恰逢沃森和克里克报道DNA双螺旋结构的那一年。在前100卷中，许多为这场革命做出贡献的科学家们在癌症研究中取得了显著的发现，这些发现推动了该领域的发展。

Category	Quartile
医学	2
医学, 肿瘤学	3

Macroenvironment-gene-microenvironment interactions in ultraviolet radiation-induced melanomagenesis.

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