Objectives– Mild cognitive impairment (MCI) has been suggested as a term for a boundary area between normal aging and dementia, especially Alzheimer's disease (AD). In follow-up studies, more than 50% of MCI subjects have been converted to dementia in 3–4 years. However, the epidemiology of MCI is not well known. This study was designed to determine the prevalence of MCI in an elderly population. Methods– A total of 806 subjects (60–76 years of age) from a population-based random sample of 1150 subjects living in the city of Kuopio in eastern Finland were evaluated. Neuropsychological tests and a structured interview including the modified Clinical Dementia Rating (CDR) were used to apply the diagnostic criteria of MCI as proposed by Mayo Clinic Alzheimer's Disease Research Centre. Thus, subjects having a test score more than 1.5 SDs below the age appropriate mean in memory tests and a CDR score of 0.5 but no dementia, were diagnosed as having MCI. Results– A total of 43 subjects, 5.3%, met the MCI criteria. MCI was more prevalent in older and less-educated subjects, but no difference was found between men and women. The CDR appeared to be the most important part of the criteria. The memory tests had less impact on prevalence variables. Conclusions– The low prevalence of MCI indicate that in a population-based study design its criteria may identify a more homogeneous group of subjects at the lower end of the cognitive continuum as contrasted with various other criteria of cognitive impairment in the elderly population. This is compatible with follow-up studies showing a high probability of dementia in the MCI group. Thus, probable candidates for trials of preventive intervention for dementia can be screened from the elderly population using these diagnostic criteria.

T. Hänninen

M. Hallikainen

S. Tuomainen

M. Vanhanen

H. Soininen

Acta Neurologica Scandinavica

ACTA NEUROLOGICA SCANDINAVICA 旨在发表代表神经科学原始临床、诊断或实验工作的高质量科学手稿。该杂志的范围是作为一个传播信息的国际论坛，以促进该学科领域的科学或实践。欢迎英文论文，特别是那些从治疗或技术应用中带来新知识和观察的论文与广泛的神经系统疾病和神经退行性疾病作斗争。将发表有关基础神经科学的相关文章，以扩展对此类疾病的当前理解。将优先审查专题主题。由于其重要性和需要快速发表的论文及时性将被列入不超过两页的“临床评论”，以及具有足够普遍兴趣的“临床评论”。鼓励以“致编辑的信”的形式进行专业内的辩论。所有提交的稿件都在总体范围内期刊的范围将由具有适当资格的审稿人进行评估。

Acta Neurologica Scandinavica aims to publish high-quality original clinical, diagnostic, or experimental manuscripts in the field of neuroscience. The journal serves as an international forum for disseminating information and promoting scientific research and practice in this discipline. We welcome papers in English, particularly those that bring new knowledge and observations from treatment or technical applications related to a wide range of neurological and neurodegenerative diseases. Articles related to basic neuroscience will also be published to enhance the current understanding of such diseases. Special topics will be prioritized for review. Due to the significance and urgency of certain papers, clinical reviews will be limited to no more than two pages, and clinically relevant reviews of broad interest will also be considered. We encourage professional debates in the form of 'letters to the editor.' All submitted manuscripts will be evaluated by appropriately qualified reviewers to ensure they fall within the overall scope of the journal.

《Acta Neurologica Scandinavica》旨在发表高质量的神经科学领域的原始临床、诊断或实验研究手稿。该杂志作为一个国际论坛，致力于传播信息，促进神经科学领域的科学研究和实践。我们欢迎英文论文，特别是那些能够为广泛的神经系统疾病和神经退行性疾病的治疗或技术应用带来新知识和观察的研究。此外，我们也会发表与基础神经科学相关的文章，以加深对这些疾病的理解。专题主题将优先审查。由于某些论文的重要性和快速发表的需求，临床评论将被限制在不超过两页，并且具有广泛兴趣的临床评论也会被考虑。我们鼓励以“致编辑的信”的形式进行专业内的辩论。所有提交的稿件将由具有适当资格的审稿人进行评估，以确保其符合期刊的总体范围。

Prevalence of mild cognitive impairment: a population-based study in elderly subjects

The low prevalence of MCI indicate that in a population‐based study design its criteria may identify a more homogeneous group of subjects at the lower end of the cognitive continuum as contrasted with various other criteria of cognitive impairment in the elderly population.

Category	Quartile
医学	3
医学, 临床神经病学	3

Prevalence of mild cognitive impairment: a population-based study in elderly subjects

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Category	Quartile
CLINICAL NEUROLOGY	2