Matrine-family alkaloids as tetracycloquinolizindine analogues from Traditional Chinese Medicine Sophora flavescens Ait, Sophora subprostrata and Sophora alopecuroides L possess various pharmacological activities and have aroused great interests over the past decades. Especially, a lot of matrine derivatives have been designed and synthesized and their biological activities investigated, and encouraging results have continuously been achieved in recent several years. These studies are helpful to develop more potent candidates or therapeutic agents and disclose their molecular targets and mechanisms. This paper reviews recent advances in the bioactive modifications of matrine-family alkaloids from derivatization of the C-13, C-14 or C-15 position, opening D ring, fusing D ring and structural simplification.

Xiao-hua Cai

Hong-yan Zhang

Bing Xie

Medicinal Chemistry

AIMS & SCOPEMEDICINAL CHEMISTRY 是一本同行评审期刊，旨在涵盖药物化学和合理药物设计方面的所有最新杰出发展。该杂志发表原创研究、小型评论文章和客座编辑的主题问题，涵盖该领域的最新研究和发展。通过充分利用互联网技术进行稿件投稿和同行评审，文章得以快速发表。药物化学是所有参与药物设计和发现的人的重要期刊。

Medicinal Chemistry is a peer-reviewed journal aimed at covering all the latest outstanding developments in the fields of medicinal chemistry and rational drug design. The journal publishes original research, short review articles, and themed issues edited by guest editors, encompassing the latest research and advancements in the field. By fully utilizing internet technology for manuscript submission and peer review, articles are published rapidly. Medicinal Chemistry is an essential journal for all those involved in drug design and discovery.

《Medicinal Chemistry》是一本经过同行评审的期刊，旨在涵盖药物化学和合理药物设计领域的最新杰出进展。该期刊发表原创研究、小型评论文章以及客座编辑的主题专刊，涉及该领域的最新研究和发展。通过充分利用互联网技术进行稿件提交和同行评审，文章得以快速发表。药物化学是所有参与药物设计和发现的研究人员的重要期刊。

Matrine-Family Alkaloids: Versatile Precursors for Bioactive Modifications

The account will review recent advances on the bioactive modifications of matrine-family alkaloids from derivatization of the C-13, C-14 or C-15 position, opening D ring, fusing D ring and structural simplification.

Category	Quartile
医学	4
医学, 药物化学	4

Matrine-Family Alkaloids: Versatile Precursors for Bioactive Modifications

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Journal Info

Category	Quartile
CHEMISTRY, MEDICINAL	3