We established both an acute and chronic cardiac toxicity rat model, which showed pretreatment with rutin attenuated pirarubicin-induced myocardial histopathological injury, electrocardiogram abnormalities, and cardiac dysfunction. Rutin also significantly reduced serum levels of MDA, BNP, CK-MB, CTnT, and LDH and increased serum SOD levels. Treatment with rutin and dexrazoxane resulted in an increase in Bcl-2/Bax ratio (p < 0.05) and reduction in JNK and Caspase-3 protein levels, compared to the pirarubicin group (all p < 0.05). Furthermore, rutin at a dose of 50 mg/kg significantly attenuated the above-mentioned alterations. Our study suggests the antioxidant and anti-apoptotic properties of rutin may be responsible for the cardioprotective effects observed.

Ya-Di Wang

Yang Zhang

Bo Sun

Xiao-Wei Leng

Ya-Juan Li

Li-Qun Ren

Journal of Asian Natural Products Research

《亚洲天然产物研究杂志》（JANPR）以英语出版亚洲民族医学天然产物研究领域的化学和药物研究。该杂志发表亚洲国家科学家的工作，例如。中国、日本、韩国和印度，包括其他国家对亚洲天然产品的贡献。该杂志以化学为导向。涵盖的主要领域有：天然成分（包括非医疗用途）的分离和结构阐明、天然产物的合成和转化（包括生物合成和生物转化）、生药学和相关主题。粗提物的生物学评估仅可作为具有良好表征结构的纯分离物的支持数据。本期刊中所有发表的研究文章都经过了严格的同行评审，基于初始编辑筛选和至少两名专家评审的匿名评审。

The Journal of Asian Natural Products Research publishes in English and focuses on the chemistry and pharmacology of natural products in Asian ethnomedicine. The journal features research from scientists in Asian countries such as China, Japan, South Korea, and India, as well as contributions from other countries regarding Asian natural products. The main areas of coverage include the isolation and structural elucidation of natural compounds, the synthesis and transformation of natural products (including biosynthesis and biotransformation), pharmacognosy, and related topics. Biological evaluations of crude extracts are only considered as supporting data for well-characterized pure isolates. All research articles published in this journal undergo rigorous peer review, which includes initial editorial screening and anonymous reviews by at least two experts.

《亚洲天然产物研究杂志》（Journal of Asian Natural Products Research）以英语出版，专注于亚洲民族医学天然产物的化学和药物研究。该杂志发表来自亚洲国家（如中国、日本、韩国和印度）科学家的研究成果，同时也欢迎其他国家对亚洲天然产品的贡献。期刊的主要研究领域包括：天然成分的分离与结构阐明、天然产物的合成与转化（包括生物合成和生物转化）、生药学及相关主题。对于粗提物的生物学评估，仅在具有良好结构表征的纯分离物的支持下进行。本期刊所有发表的研究文章均经过严格的同行评审，评审过程包括初步编辑筛选和至少两名专家的匿名评审。

Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity

The antioxidant and anti-apoptotic properties of rutin may be responsible for the cardioprotective effects observed in an acute and chronic cardiac toxicity rat model.

Category	Quartile
医学	3
医学, 应用化学	4
医学, 药物化学	4
医学, 药学	4
医学, 植物科学	4

Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity

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Category	Quartile
PLANT SCIENCES	3