Background: Panallergens are proteins that take part in key processes of organisms and, therefore, are ubiquitously distributed with highly conserved sequences and structures. One class of these panallergens is composed of the tropomyosins. The highly heat-stable tropomyosins comprise the major allergens in crustaceans and mollusks, which make them important food allergens in exposed populations. Tropomyosins are responsible for a widespread immunoglobulin E cross-reactivity among allergens from different sources. Allergic tropomyosins are expressed in many species, including parasites and insects. Methods: This panallergen class is divided, according to it capacity of induced allergic symptoms, into allergenic or nonallergenic tropomyosin. Although vertebrate tropomyosins share ∼55% of sequence homology with invertebrate tropomyosins, it has been thought that the invertebrate tropomyosins would not have allergic properties. Nevertheless, in recent years, this opinion has been changed. In particular, tropomyosin has been recognized as a major allergen in many insects. Results: A high grade of homology has been shown among tropomyosins from different species, such as crustaceans and insects, which supports the hypothesis of cross-reactivity among tropomyosins from divergent species. Moreover, the emerging habit of consuming edible insects has drawn the attention of allergists to invertebrate tropomyosin protein due to its potential allergenic risk. Nevertheless, evidence about tropomyosin involvement in clinical allergic response is still scarce and deserves more investigation. Conclusion: This review intended to report allergic reactions associated with different tropomyosins when considering house dust mites, parasites, seafood, and insects, and to summarize our current knowledge about its cross-reactivity because this could help physicians to accurately diagnose patients with food allergy.

Francesco Papia

Chiara Bellia

Carina Gabriela Uasuf

Allergy and Asthma Proceedings

ALLERGY & ASTHMA PROCEEDINGS 是一份同行评审出版物，致力于及时发布有关过敏、哮喘和免疫学知识和实践进展的科学研究。它的主要读者群包括过敏症专家和肺病专家。会议论文集的目标是发表以临床为主的文章，这些文章直接影响过敏性疾病和哮喘患者的护理质量。特色主题包括哮喘、鼻炎、鼻窦炎、食物过敏、过敏性皮肤病、诊断技术、过敏原和治疗方式。发表的材料包括同行评审的原始研究、临床试验和评论文章。

Allergy and Asthma Proceedings is a peer-reviewed journal dedicated to the timely publication of scientific research related to advances in allergy, asthma, and immunology. Its primary readership includes allergy specialists and pulmonologists. The journal aims to publish clinically focused articles that directly impact the quality of care for patients with allergic diseases and asthma. Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment methods. Published materials include peer-reviewed original research, clinical trials, and review articles.

《Allergy and Asthma Proceedings》是一本经过同行评审的学术期刊，专注于及时发布与过敏、哮喘和免疫学相关的科学研究进展。其主要读者群体包括过敏症专家和肺病专家。期刊旨在发表以临床为主的文章，这些文章直接影响过敏性疾病和哮喘患者的护理质量。特色主题涵盖哮喘、鼻炎、鼻窦炎、食物过敏、过敏性皮肤病、诊断技术、过敏原及治疗方法。发表的内容包括经过同行评审的原始研究、临床试验和评论文章。

Tropomyosin: A panallergen that causes a worldwide allergic problem

A high grade of homology has been shown among tropomyosins from different species, such as crustaceans and insects, which supports the hypothesis of cross-reactivity among Tropomyosin from divergent species.

Category	Quartile
医学	3
医学, 过敏	4

Tropomyosin: A panallergen that causes a worldwide allergic problem

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