Calcitonin gene-related peptide (CGRP) has been viewed as a neuropeptide and vasodilator. However, CGRP is more appropriately thought of as a pleiotropic signalling molecule. Indeed, CGRP has key regulatory functions on immune and inflammatory processes within the skin. CGRP-containing nerves are intimately associated with epidermal Langerhans cells (LCs), and CGRP has profound regulatory effects on Langerhans cell antigen-presenting capability. When LCs are exposed to CGRP in vitro, their ability to present antigen for in vivo priming of naïve mice or elicitation of delayed-type hypersensitivity is inhibited in at least some situations. Administration of CGRP intradermally inhibits acquisition of immunity to Th1-dominant haptens applied to the injected site while augmenting immunity to Th2-dominant haptens, although the cellular targets of activity in these experiments remain unclear. Although CGRP can be a pro-inflammatory agent, several studies have demonstrated that administration of CGRP can inhibit the elicitation of inflammation by inflammatory stimuli in vivo. In this regard, CGRP inhibits the release of certain chemokines by stimulated endothelial cells. This is likely to be physiologically relevant as cutaneous blood vessels are innervated by sensory nerves. Exciting new studies suggest a significant role for CGRP in the pathogenesis of psoriasis and, most strikingly, that CGRP inhibits the ability of LCs to transmit the human immunodeficiency virus 1 to T lymphocytes. A more complete understanding of the role of CGRP in the skin immune system may lead to new and novel approaches for the therapy of immune-mediated skin disorders.

R. D. Granstein

J. A. Wagner

L. L. Stohl

W. Ding

Acta Physiologica

ACTA PHYSIOLOGICA 是一个重要论坛，用于发表来自世界各地的作者在生理学和相关领域的高质量原创研究。 ACTA PHYSIOLOGICA 是人类/转化生理学领域的领先期刊，同时促进了生理学科学的各个方面。该杂志发表关于重要的新观察以及评论和评论的完整原创文章。

Acta Physiologica is an important academic forum dedicated to publishing high-quality original research from authors around the world in the fields of physiology and related areas. As a leading journal in human/translational physiology, Acta Physiologica promotes various aspects of physiological science. The journal publishes significant new observations, as well as complete original articles, reviews, and commentaries.

《Acta Physiologica》是一个重要的学术论坛，致力于发表来自全球作者在生理学及相关领域的高质量原创研究。作为人类/转化生理学领域的领先期刊，《Acta Physiologica》促进了生理学科学的各个方面。该杂志发表重要的新观察，以及完整的原创文章、评论和综述。

Calcitonin gene‐related peptide: key regulator of cutaneous immunity

Exciting new studies suggest a significant role for C GRP in the pathogenesis of psoriasis and, most strikingly, that CGRP inhibits the ability of LCs to transmit the human immunodeficiency virus 1 to T lymphocytes.

Category	Quartile
医学	2
医学, 生理学	1

Calcitonin gene‐related peptide: key regulator of cutaneous immunity

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info