ABSTRACT Major depressive disorder (MDD) is a common psychiatric condition that causes considerable morbidity and disability. MDD is characterized by recurrent depressive episodes that can result in loss of productivity, job insecurity, social isolation, and suicidality. Primary care providers frequently provide the initial management of MDD; however, some patients do not respond to first- or second-line treatments, a condition called treatment-resistant depression (TRD). Understanding how to accurately diagnose and manage TRD is important for clinicians.

Cyrus Ma

Brittany Strelow

JAAPA

​​​JAAPA is the peer-reviewed clinical journal of the American Academy of Physician Assistants (AAPA). Published for more than 25 years, its mission is to support the ongoing education and advancement of physician assistants (PAs) by publishing current information and research on clinical, health policy, and professional issues.

Published monthly, JAAPA's award-winning editorial includes:

-Clinical review articles (with AAPA-approved Category I CME in each issue)-
Case reports-
Clinical departments-
Original health services research-
Articles on issues of professional interest to PAs

JAAPA (Journal of the American Academy of Physician Assistants) is the peer-reviewed clinical journal of the American Academy of Physician Assistants (AAPA). Published for over 25 years, its mission is to support the ongoing education and advancement of physician assistants (PAs) by publishing current information and research on clinical, health policy, and professional issues. Published monthly, JAAPA's award-winning editorial includes: clinical review articles (with AAPA-approved Category I CME in each issue), case reports, clinical departments, original health services research, and articles on issues of professional interest to PAs.

JAAPA（美国医师助理协会官方期刊）是美国医师助理协会（AAPA）的一本经过同行评审的临床期刊。该期刊已出版超过25年，旨在通过发布关于临床、健康政策和专业问题的最新信息和研究，支持医师助理（PAs）的持续教育和职业发展。JAAPA每月出版，获奖的编辑内容包括：临床综述文章（每期均附有AAPA批准的I类CME）、病例报告、临床部门、原创健康服务研究，以及与PAs专业相关的问题文章。

Category	Quartile
医学	4
医学, 医学内科	4

Recognition and management of treatment-resistant depression

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Journal Info

Category	Quartile
MEDICINE, GENERAL & INTERNAL	3