Objective Recent research has explored frailty in systemic lupus erythematosus (SLE) using multiple measures. We examined the agreement among frailty measures and the association of each with cross‐sectional and longitudinal health outcomes. Methods We used data from the California Lupus Epidemiology Study (CLUES) to examine the following measures of frailty: Systemic Lupus International Collaborating Clinics (SLICC) Frailty Index (SLICC‐FI), Short Physical Performance Battery (SPPB), and Fatigue, Resistance, Ambulation, Illness, and Loss of Weight (FRAIL) scale questionnaire. PROMIS Physical Function 10a (PF) was tested as a proxy measure of frailty. Agreement between frailty classifications by each measure was assessed. Cross‐sectional associations of frailty classifications with hospitalization, valued life activities disability, cognitive impairment, 6‐minute walk test distance, self‐reported disease damage, fatigue, and depressive symptoms were assessed with logistic and linear regression analyses. Associations with hospitalization, disease damage increase, and disability increase over the subsequent 3 years were assessed Cox proportional hazards analyses. Results Percentages of participants identified as frail varied among the measures, from 10.8% to 45.9%. Agreement among classifications ranged from slight to substantial (κ from 0.17 to 0.63). Most of the frailty measures were associated with both cross‐sectional and longitudinal health outcomes, with the notable exception of the SPPB. SLICC‐FI had the most consistent association with outcomes, followed by FRAIL and PF. Conclusion Multiple measures of frailty appear to identify the risk of poor health outcomes. The intended use, as well as the simplicity and practicality of implementing the measure, may be the most important considerations in choosing a frailty measure.

Patricia Katz

Maria Dall'Era

Laura Plantinga

Kamil E. Barbour

Kurt J. Greenlund

Jinoos Yazdany

Arthritis Care & Research

ARTHRITIS CARE & RESEARCH 是美国风湿病学会和风湿病健康专业人员协会（学院的一个部门）的官方期刊，是一份同行评议的出版物，发表原创研究、评论文章和社论，以促进在风湿病临床实践。与风湿病患者的护理相关，主要主题是循证实践研究、临床问题、实践指南、教育、社会和公共卫生问题、卫生经济学、卫生保健政策以及风湿病实践的未来趋势。

Arthritis Care and Research is the official journal of the American College of Rheumatology and the Association of Rheumatology Health Professionals (a division of the college). This peer-reviewed publication features original research, review articles, and editorials aimed at advancing clinical practice in rheumatology. The journal primarily addresses topics related to the care of patients with rheumatic diseases, including evidence-based practice research, clinical issues, practice guidelines, education, social and public health issues, health economics, healthcare policy, and future trends in rheumatology practice.

《Arthritis Care and Research》是美国风湿病学会和风湿病健康专业人员协会（学院的一个部门）的官方期刊。这是一份经过同行评审的学术期刊，发表原创研究、评论文章和社论，旨在促进风湿病的临床实践。期刊主要关注与风湿病患者护理相关的主题，包括循证实践研究、临床问题、实践指南、教育、社会和公共卫生问题、卫生经济学、卫生保健政策以及风湿病实践的未来趋势。

Category	Quartile
医学	2
医学, 风湿病学	3

Measuring Frailty in Systemic Lupus Erythematosus

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info