ABSTRACT Introduction Inflammation is a marker of immune activation. Inflammation may have an effect on both ovarian function and luteal function, both essential to pregnancy. High inflammation may also signal dysregulated processes within the ovary, which could be in part measured through Anti‐Müllerian hormone, follicle‐stimulating hormone, and inhibin B levels. Objective To determine the relationship between inflammation, measured by C‐reactive protein, and three biomarkers of ovarian function during the early follicular phase: Anti‐Müllerian hormone, follicle‐stimulating hormone, and inhibin B. Methods Secondary cross‐sectional analysis of data and serum obtained in Time to Conceive, a prospective cohort study sample of 843 women attempting pregnancy in central North Carolina from 2008 to 2016. Participants were aged 30 and 44 years, had no history of infertility, endometriosis, or polycystic ovarian syndrome, and were not currently breastfeeding. Serum samples were obtained on days 2, 3, or 4 of the menstrual cycle. C‐reactive protein (natural‐log transformed), Anti‐Müllerian hormone (natural‐log transformed), follicle‐stimulating hormone (natural‐log transformed), and inhibin B (untransformed) were measured in serum. Diminished ovarian reserve was examined dichotomously and defined as an Anti‐Müllerian hormone level below 0.7 ng/mL. Results The analysis included 703 participants with C‐reactive protein measured. In an adjusted linear regression model, a 20% increase in C‐reactive protein was associated with a 0.57 pg/mL decrease in inhibin B (95% CI: −0.84 to −0.29 pg/mL) and a 0.535% decrease in follicle‐stimulating hormone (95% CI: −1.01 to −0.06). Although there was not a significant relationship between Anti‐Müllerian hormone and C‐reactive protein, a 20% increase in C‐reactive protein was associated with a 0.87% increase in Anti‐Müllerian hormone (95% CI: −0.27 to 2.01). C‐reactive protein was not associated with the odds of diminished ovarian reserve in an adjusted logistic regression model (OR: 0.97, 95% CI: 0.77–1.20). Conclusions Inflammation, as measured by C‐reactive protein, is associated with early follicular phase follicle‐stimulating hormone and inhibin B, although this is not true of AMH. Inflammation may exert an effect on ovarian function.

Anneliese Long

Anne Z. Steiner

Amanda L. Thompson

Hannah R. Jahnke

Benjamin S. Harris

Anne Marie Jukic

American Journal of Human Biology

美国人类生物学杂志是人类生物学协会的官方期刊。美国人类生物学杂志是一个双月刊，同行评议，国际发行的期刊，发表原创研究报告、理论文章和及时评论，并在人类生物学的跨学科领域。作为人类生物学协会的官方期刊，该杂志还出版在其年度科学会议上发表的研究摘要和与该领域相关的书评。该杂志寻求涉及人类生物学、健康和疾病各个方面的学术手稿，特别是那些强调比较、发展、生态或进化观点的观点。该杂志涵盖的跨学科领域包括但不限于流行病学、遗传变异、人口生物学和人口学、生理学、解剖学、营养学、生长和衰老、身体表现、身体活动和健身、生态学和进化，以及他们的互动。该杂志发表来自所有领域的基础、应用和方法导向的研究，包括人类生物学中的测量、分析技术和策略以及计算机应用。与许多其他生物学导向的学科一样，人类生物学领域在最近经历了相当大的发展和多样化年，期刊目标和范围的扩大反映了这种增长和会员多元化。期刊致力于及时审查，优先出版具有新颖或及时发现的手稿，以及不寻常的兴趣手稿.

The American Journal of Human Biology is the official journal of the Human Biology Association. This bi-monthly, peer-reviewed journal is published internationally and focuses on original research reports, theoretical articles, and timely reviews in the interdisciplinary field of human biology. As the official journal of the Human Biology Association, it also publishes research abstracts presented at its annual scientific meetings and relevant book reviews. The journal seeks academic manuscripts that address various aspects of human biology, health, and disease, particularly those emphasizing comparative, developmental, ecological, or evolutionary perspectives. The interdisciplinary areas covered by the journal include, but are not limited to, epidemiology, genetic variation, population biology and demography, physiology, anatomy, nutrition, growth and aging, physical performance, physical activity and fitness, ecology and evolution, and their interactions. The journal publishes foundational, applied, and methods-oriented research from all fields, including measurement, analytical techniques, strategies, and computer applications in human biology. Like many other biology-oriented disciplines, the field of human biology has experienced significant growth and diversification in recent years, and the journal's goals and scope have expanded to reflect this growth and the diversity of its membership. The journal is committed to timely reviews and prioritizes the publication of manuscripts with novel or timely findings, as well as those of unusual interest.

《American Journal of Human Biology》是人类生物学协会的官方期刊。该期刊为双月刊，经过同行评审，国际发行，主要发表原创研究报告、理论文章和及时评论，涵盖人类生物学的跨学科领域。作为人类生物学协会的官方出版物，期刊还会发布在其年度科学会议上发表的研究摘要和相关书评。期刊欢迎涉及人类生物学、健康和疾病各个方面的学术手稿，特别是那些强调比较、发展、生态或进化视角的研究。期刊涵盖的跨学科领域包括但不限于流行病学、遗传变异、人口生物学和人口学、生理学、解剖学、营养学、生长与衰老、身体表现、身体活动与健身、生态学和进化及其相互作用。期刊发表来自各个领域的基础研究、应用研究和方法导向的研究，包括人类生物学中的测量、分析技术和策略以及计算机应用。近年来，人类生物学领域经历了显著的发展和多样化，期刊的目标和范围也随之扩大，以反映这一增长和会员的多元化。期刊致力于及时审查，优先出版具有新颖或及时发现的手稿，以及不寻常的研究。

Category	Quartile
医学	4
医学, 生物学	3
医学, 人类学	4

Inflammation and Ovarian Function in Reproductive‐Aged Women

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