Elephantiasis nostras verrucosa is a rare disorder that results from chronic obstructive lymphedema. It is characterized clinically by deforming, nonpitting edema; malodorous hyperkeratosis with generalized lichenification; cobblestoned papules; and verrucous changes, that often result in extreme enlargement of the involved body part. Although elephantiasis nostras verrucosa is striking in clinical appearance, biopsy reveals only moderately abnormal findings: pseudoepitheliomatous hyperplasia with dilated lymphatic spaces in the dermis, accompanied by chronic inflammation and fibroblast proliferation. The term elephantiasis nostras (nostras means "from our region") has traditionally been used to differentiate temperate zone disease from the classic disease process, elephantiasis tropica, which is defined by chronic filarial lymphatic obstruction caused by Wuchereria bancrofti, Wuchereria malayi, or Wuchereria pacifica. We present a case report of elephantiasis nostras verrucosa arising as a result of lymphedema praecox.

Amy L. Duckworth

Jugnoo Husain

Patrick DeHeer

Journal of the American Podiatric Medical Association

美国足病医学协会杂志是该协会的官方期刊，是足踝医学领域历史最悠久、被引用次数最多的同行评审期刊。它成立于 1907 年，每年出版 6 次，出版研究报告、病例报告、文献综述、特殊通讯、临床通信、致编辑的信函、书评和各种其他类型的投稿。该期刊被收录在生物医学文献的主要索引和摘要服务中。

The Journal of the American Podiatric Medical Association is the official journal of the American Podiatric Medical Association and is the oldest and most cited peer-reviewed journal in the field of foot and ankle medicine. Established in 1907, it publishes six issues per year, featuring research articles, case reports, literature reviews, special communications, clinical communications, letters to the editor, book reviews, and various other types of submissions. The journal is indexed in major biomedical literature indexing and abstracting services.

《Journal of the American Podiatric Medical Association》是美国足病医学协会的官方期刊，也是足踝医学领域历史最悠久、引用次数最多的同行评审期刊。该期刊成立于1907年，每年出版6期，涵盖研究报告、病例报告、文献综述、特别通讯、临床通信、致编辑的信函、书评及其他多种类型的投稿。该期刊被主要的生物医学文献索引和摘要服务收录。

Elephantiasis Nostras Verrucosa or “Mossy Foot Lesions” in Lymphedema Praecox

Although elephantiasis nostras verrucosa is striking in clinical appearance, biopsy reveals only moderately abnormal findings: pseudoepitheliomatous hyperplasia with dilated lymphatic spaces in the dermis, accompanied by chronic inflammation and fibroblast proliferation.

Category	Quartile
医学	4
医学, 骨科	4

Elephantiasis Nostras Verrucosa or “Mossy Foot Lesions” in Lymphedema Praecox

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