To provide an overview of the complexities associated with the human leukocyte antigen (HLA)-mediated platelet refractoriness. HLA antibody detection technologies and limitations associated with methodologies are discussed. A case scenario and review of relevant literature describing platelet refractoriness are presented, followed by a discussion of HLA antibody testing. Following diagnosis of HLA-mediated refractoriness, a decision is made regarding the approach to obtain the appropriate platelets. The panel reactive antibodies (PRA) % of the patient, HLA typing, and limitations of the HLA testing should be taken into account when deciding which type of product would be the best option for a given patient. Following confirmation and review of HLA antibody testing, platelets are ordered based upon the PRA% and approach employed, HLA-matched platelets, antigen restricted platelets, or cross-matched platelets. The platelets are transfused and a posttransfusion increment count is monitored to determine transfusion success.

Amy E Schmidt

Majed A Refaai

Myra Coppage

American Journal of Clinical Pathology

美国临床病理学杂志 (AJCP) 是美国临床病理学会和临床实验室医师和科学家学会的官方期刊。它是出版有关人类疾病的新型解剖病理学和实验室医学观察文章的领先国际期刊。 AJCP 强调的文章侧重于将不断发展的技术应用于疾病和状况的诊断和表征，以及与改善患者护理有直接联系的文章。

The American Journal of Clinical Pathology is the official journal of the American Society for Clinical Pathology and the Society of Clinical Laboratory Scientists. It is a leading international journal that publishes innovative articles on anatomic pathology and laboratory medicine observations related to human diseases. The journal emphasizes articles that focus on the application of evolving technologies in the diagnosis and characterization of diseases and conditions, as well as those that are directly linked to improving patient care.

《American Journal of Clinical Pathology》是美国临床病理学会和临床实验室医师与科学家学会的官方期刊。该期刊是国际领先的出版有关人类疾病的解剖病理学和实验室医学观察文章的期刊。它强调的文章主要集中在将不断发展的技术应用于疾病和病症的诊断与表征，以及与改善患者护理直接相关的研究。

HLA-Mediated Platelet Refractoriness

The panel reactive antibodies (PRA) % of the patient, HLA typing, and limitations of the HLA testing should be taken into account when deciding which type of product would be the best option for a given patient.

Category	Quartile
医学	4
医学, 病理学	3

HLA-Mediated Platelet Refractoriness

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info