Neuroinflammation can be an important factor of many disorders in central nervous system (CNS) including cognitive dysfunction, affective disorders, and addictive behavior associated with prenatal alcohol exposure and presented in early adulthood. In this study we used an experimental rodent model of prenatal alcohol (PA) exposure (consumption of a 10% ethanol solution by female Wistar rats throughout pregnancy), multiplex immunofluorescence analysis of interleukins (IL-1α, IL-1β, IL-3, IL-6, IL-9, and IL-12), tumor necrosis factor (TNF-α), and chemokine CCL5, as well as quantitative real-time PCR to assess the level of cytokine mRNAs in the prefrontal cortex of the sexually mature (PND60) offspring - male and female rats with prenatal alcohol intoxication and control animals. Significant decrease in the content of TNF-α and interleukins IL-1β, IL-3, IL-6, IL-9 was detected in the prefrontal cortex of male, but not in the female PA offspring. Importantly, PA males also showed decrease in the level of TNF-α mRNA in the prefrontal cortex by 45% compared to the control males, which may underlie the detected decrease in its content. Taken together, our study demonstrates that a number of neuroimmune factors are regulated in a sex-specific manner in the prefrontal cortex and are differentially affected in males and females by the prenatal exposure to alcohol. Sex factor must be taken into account when conducting further translational studies of the fetal alcohol spectrum disorders and developing new methods for prevention and therapy.

Inna Yu Shamakina

Petr K Anokhin

Ruslan A Ageldinov

Viktor S Kokhan

Biochemistry (Moscow)

BIOCHEMISTRY (MOSCOW) 是一本收录生物化学所有领域以及分子生物学、生物有机化学、微生物学、免疫学、生理学和生物医学科学的生化方面的研究论文的期刊。报道还延伸到生物化学的新实验方法、生化重要性的理论贡献、当代生化主题的评论和小型评论（生物化学新闻）。

Biochemistry (Moscow) is a journal that covers all areas of biochemistry, including research papers in molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. The journal also reports on new experimental methods in biochemistry, theoretical contributions of significant importance, and reviews and brief commentaries on contemporary biochemical topics (Biochemistry News).

《Biochemistry (Moscow)》是一本涵盖生物化学各个领域的期刊，涉及分子生物学、生物有机化学、微生物学、免疫学、生理学和生物医学科学的研究论文。期刊内容还包括生物化学的新实验方法、理论贡献以及当代生化主题的评论和简短综述（生物化学新闻）。

Category	Quartile
生物学	4
生物学, 生化与分子生物学	4

Neuroimmune Characteristics of Animals with Prenatal Alcohol Intoxication

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