Abstract Stem cells play a critical role in human tissue regeneration and repair. In addition, cancer stem cells (CSCs), subpopulations of cancer cells sharing similar characteristics as normal stem cells, are responsible for tumor metastasis and resistance to chemo‐ and radiotherapy and to tumor relapse. Interestingly, all stem cells have cannabinoid receptors, such as cannabidiol (CBD), that perform biological functions. The aim of this systematic review was to analyze the effect of CBD on both somatic stem cells (SSCs) and CSCs. Of the 276 articles analyzed, 38 were selected according to the inclusion and exclusion criteria. A total of 27 studied the effect of CBD on SSCs, finding that 44% focused on CBD differentiation effect and 56% on its protective activity. On the other hand, 11 articles looked at the effect of CBD on CSCs, including glioblastoma (64%), lung cancer (27%), and breast cancer (only one article). Our results showed that CBD exerted a differentiating and protective effect on SCCs. In addition, this molecule demonstrated an antiproliferative effect on some CSCs, although most of the analyses were performed in vitro. Therefore, although in vivo studies should be necessary to justify its clinical use, CBD and its receptors could be a specific target to act on both SSCs and CSCs.

Cristina Mesas

Javier Moreno

Kevin Doello

Mercedes Peña

Juan M. López‐Romero

Jose Prados

Consolación Melguizo

BioFactors

BIOFACTORS 是国际生物化学和分子生物学联盟的期刊，致力于快速发表在健康和疾病的实验生物学中具有高度重要意义的原创研究文章和评论。“生物因子”一词是指调节生物功能的许多化合物.生物因素包括由生物体产生或修饰的许多分子，并存在于许多基本系统中，如血液、神经或免疫系统。生物因子的非详尽列表包括神经递质、细胞因子、趋化因子、激素、凝血因子、转录因子、信号分子、受体配体等等。在生物因子组中，我们可以容纳几种未在体内合成的经典分子，例如维生素、微量营养素或必需的微量元素。为了与生物化学的这一统一观点保持一致，BIOFACTORS 发表了关于新物质鉴定及其阐明的研究生物物理、生化、细胞和人类水平的功能，以及揭示已知生物因子新功能的研究。该杂志鼓励提交使用生物化学、生物物理学、细胞和分子生物学和/或细胞信号传导方法的研究。

BIOFACTORS is a journal of the International Union of Biochemistry and Molecular Biology, dedicated to the rapid publication of original research articles and reviews that are highly significant in experimental biology related to health and disease. The term 'biofactors' refers to a variety of compounds that regulate biological functions. Biofactors include many molecules produced or modified by living organisms, which are present in various fundamental systems such as blood, the nervous system, and the immune system. Examples of biofactors include neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, and receptor ligands. Additionally, BIOFACTORS accommodates several classical molecules that are not synthesized in the body, such as vitamins, trace nutrients, and essential trace elements. In alignment with this unified view of biochemistry, BIOFACTORS publishes research on the identification of new substances and their elucidation of functions at the biophysical, biochemical, cellular, and human levels, as well as studies revealing new functions of known biofactors. The journal encourages submissions that utilize biochemical, biophysical, cellular, and molecular biology and/or cell signaling methods.

BIOFACTORS 是国际生物化学和分子生物学联盟的期刊，专注于快速发表在健康与疾病领域具有重要意义的原创研究文章和评论。‘生物因子’指的是调节生物功能的多种化合物，包括由生物体产生或修饰的分子，这些分子存在于许多基本系统中，如血液、神经系统和免疫系统。生物因子的例子包括神经递质、细胞因子、趋化因子、激素、凝血因子、转录因子、信号分子和受体配体等。此外，BIOFACTORS 也欢迎关于一些经典分子（如维生素、微量营养素和必需微量元素）的研究，这些分子并非在体内合成。为了与生物化学的统一观点保持一致，BIOFACTORS 发表关于新物质的鉴定及其在生物物理、生化、细胞和人类水平的功能研究，以及揭示已知生物因子新功能的研究。该期刊鼓励提交使用生物化学、生物物理学、细胞和分子生物学及/或细胞信号传导方法的研究。

Category	Quartile
生物学	3
生物学, 生化与分子生物学	3
生物学, 内分泌学与代谢	3

Cannabidiol effects in stem cells: A systematic review

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Journal Info

Category	Quartile
ENDOCRINOLOGY & METABOLISM	1