Epidermal melanocytes (MC) are pigment-producing and secretorily active cells of neural crest origin that communicate directly with multiple targets. Here, we propose that normal epidermal MC also are "sensory" and regulatory cells operating in the context of a regulatory network for the maintenance of human epidermal homeostasis. Altered regulatory MC functions may play a role in selected skin diseases, and racial pigmentation may affect cutaneous functions.

Andrzej Slominski

Ralf Paus

Dirk Schadendorf

Journal of Theoretical Biology

理论生物学杂志是深入了解生物过程的理论观点的主要论坛。它涵盖了非常广泛的主题，并引起了许多研究领域的生物学家的兴趣，包括：• 脑和神经科学• 癌症生长和治疗• 细胞生物学• 发育生物学• 生态学• 进化• 免疫学• 传染性和非传染性疾病，• 数学、计算、生物物理和统计建模• 微生物学、分子生物学和生物化学• 网络和复杂系统• 生理学• 药效学• 动物行为和博弈论可接受的论文是那些对生物学本身具有重要意义的论文，以及不在数学分析上。包含一些与理论相关的数据或实验材料的论文将被考虑，包括那些包含比较研究、统计数据分析、数学证明、计算机模拟、实验、实地观察甚至哲学论证的论文，这些都是支持或拒绝的方法理论思想。然而，应该齐心协力使论文对所选领域的生物学家更易理解。

The Journal of Theoretical Biology serves as a primary forum for exploring theoretical perspectives on biological processes. It covers a wide range of topics that attract the interest of biologists from various research fields, including: brain and neuroscience, cancer growth and treatment, cell biology, developmental biology, ecology, evolution, immunology, infectious and non-infectious diseases, mathematical, computational, biophysical, and statistical modeling, microbiology, molecular biology, and biochemistry, networks and complex systems, physiology, pharmacology, animal behavior, and game theory. Acceptable papers are those that hold significant importance for biology itself, rather than merely focusing on mathematical analysis. Papers that include some data or experimental materials related to theory will also be considered, including those that contain comparative studies, statistical data analysis, mathematical proofs, computer simulations, experiments, field observations, or even philosophical arguments that support or refute theoretical ideas. However, efforts should be made to ensure that the papers are more easily understood by biologists in the selected field.

《Journal of Theoretical Biology》是一个主要论坛，旨在深入探讨生物过程的理论视角。该期刊涵盖了广泛的主题，吸引了众多生物学研究领域的学者关注，包括：脑与神经科学、癌症生长与治疗、细胞生物学、发育生物学、生态学、进化、免疫学、传染性与非传染性疾病、数学、计算、生物物理与统计建模、微生物学、分子生物学与生物化学、网络与复杂系统、生理学、药效学、动物行为与博弈论。接受的论文应对生物学本身具有重要意义，而不仅仅是数学分析。包含与理论相关的数据或实验材料的论文也将被考虑，包括比较研究、统计数据分析、数学证明、计算机模拟、实验、实地观察甚至哲学论证，这些都旨在支持或反驳理论思想。然而，论文应努力使其内容对所选领域的生物学家更易理解。

Melanocytes as "Sensory" and Regulatory Cells in the Epidermis

It is proposed that normal epidermal MC also are "sensory" and regulatory cells operating in the context of a regulatory network for the maintenance of human epidersmal homeostasis.

Category	Quartile
数学	4
数学, 生物学	4
数学, 数学与计算生物学	4

Melanocytes as "Sensory" and Regulatory Cells in the Epidermis

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Journal Info

Category	Quartile
MATHEMATICAL & COMPUTATIONAL BIOLOGY	3