We have generated a novel composite organ, the thymoheart, which facilitates the contemporaneous transfer of fully vascularized and functional donor thymic tissue to the host at the time of cardiac transplantation. Composite thymoheart allografts were prepared in MHC-inbred miniature swine by implanting autologous thymic tissue into donor hearts 60–90 days before organ procurement. Thymoheart allografts and unmanipulated control hearts were then transplanted into three groups, each treated with the same 12 days of cyclosporine. MHC-matched thymohearts transplanted into euthymic recipients had a minimum survival ranging between 72 and 194 days vs. 42–64 days for unmanipulated control hearts (p = 0.02). MHC class I-disparate thymohearts transplanted into euthymic recipients had a minimum survival ranging between 64 and 191 days vs. 30–55 days for unmanipulated control hearts (p = 0.01). MHC class I-disparate thymohearts transplanted into thymectomized recipients survived between 41 and 70 days vs. 8–27 days for unmanipulated control hearts (p = 0.01). Cellular and humoral functional assays, and skin grafting, confirmed the presence of donor-specific hyporesponsiveness in long-term thymoheart allografts recipients. The transfer of vascularized, functional donor thymic tissue to the host at the time of cardiac transplantation may provide a novel approach to the induction of tolerance in human heart transplant recipients.

Matthew T. Menard

Margaret L. Schwarze

James S. Allan

Douglas R. Johnston

Kwabena Mawulawde

Akira Shimizu

Kazuhiko Yamada

Stuart L. Houser

Kenneth S. Allison

David H. Sachs

Joren C. Madsen

American Journal of Transplantation

范围是国际移植学科。这包括器官和组织的捐赠和保存；组织损伤、修复、炎症和老化；免疫识别、调节、效应机制和诱导耐受的机会；组织相容性；与移植相关的药物和药理学；移植物存活和预防移植物功能障碍和失败；临床试验和人群分析；移植并发症；异种移植；以及伦理和社会问题。科学包括细胞生物学、医学、外科、儿科和传染病的相关方面。该杂志包括胸腔移植（心脏、肺）、腹部移植（肾、肝、胰腺、胰岛）、组织移植和相关主题。

The American Journal of Transplantation is a journal that covers the field of international transplantation. This includes organ and tissue donation and preservation; tissue injury, repair, inflammation, and aging; immune recognition, regulation, mechanisms of action, and opportunities for inducing tolerance; tissue compatibility; drugs and pharmacology related to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses; transplant complications; xenotransplantation; as well as ethical and social issues. The scientific scope includes relevant aspects of cell biology, medicine, surgery, pediatrics, and infectious diseases. The journal covers thoracic transplantation (heart, lung), abdominal transplantation (kidney, liver, pancreas, islet), tissue transplantation, and related topics.

《American Journal of Transplantation》是一个涵盖国际移植学科的期刊，内容包括器官和组织的捐赠与保存、组织损伤与修复、炎症与老化、免疫识别与调节机制、组织相容性、与移植相关的药物与药理学、移植物存活及预防移植物功能障碍和失败的研究、临床试验与人群分析、移植并发症、异种移植以及伦理与社会问题。该期刊涉及细胞生物学、医学、外科、儿科和传染病等相关领域，涵盖胸腔移植（心脏、肺）、腹部移植（肾、肝、胰腺、胰岛）、组织移植及相关主题。

Composite ‘Thymoheart’ Transplantation Improves Cardiac Allograft Survival

The transfer of vascularized, functional donor thymic tissue to the host at the time of cardiac transplantation may provide a novel approach to the induction of tolerance in human heart transplant recipients.

Category	Quartile
医学	2
医学, 移植	1
医学, 外科	2

Composite ‘Thymoheart’ Transplantation Improves Cardiac Allograft Survival

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