The conjugation of heterocyclic compounds often aims to leverage the beneficial properties of multiple compounds, which ultimately motivate the researchers to develop novel medicines with better efficacy, affinity, modified selectivity, dual/various modes of action, reduced side effects, lower cost, or enhanced therapeutic profiles. Hybrid molecules or conjugates for synergistic effect are obtained by combining structural features of two differently active fragments. Due to 1,3,4-oxadiazole’s alternating single and double bonds, each atom providing a porbital perpendicular to the molecule's plane is stabilized like a drug molecule. The conjugate of 1,3,4-oxadiazole with piperazine moiety exhibits a range of physiological effects such as lowering blood pressure, antimicrobial, antitubercular, antioxidant, anticancer, antiproliferative, etc. Numerous natural molecules with pharmacological importance have also been found to possess conjugation between piperazine and 1,3,4-oxadiazole. As there is a lack of studies that focused on the synthetic protocols, pharmacological potential, and structure-activity relationship of the conjugates of 1,3,4-oxadiazoles and piperazines, the presented article highlights specifically these dimensions which have been reported in the last 10 years (2014-2024) These details assist researchers in designing their studies, and it is hoped that researchers from various scientific fields will find the manuscript beneficial for their future work on the conjugates of 1,3,4-oxadiazoles and piperazine.

Upasana Sharma

Rajnish Kumar

Avijit Mazumder

None Salahuddin

Pankaj Kumar Tyagi

Saurabh Singh

Medicinal Chemistry

AIMS & SCOPEMEDICINAL CHEMISTRY 是一本同行评审期刊，旨在涵盖药物化学和合理药物设计方面的所有最新杰出发展。该杂志发表原创研究、小型评论文章和客座编辑的主题问题，涵盖该领域的最新研究和发展。通过充分利用互联网技术进行稿件投稿和同行评审，文章得以快速发表。药物化学是所有参与药物设计和发现的人的重要期刊。

Medicinal Chemistry is a peer-reviewed journal aimed at covering all the latest outstanding developments in the fields of medicinal chemistry and rational drug design. The journal publishes original research, short review articles, and themed issues edited by guest editors, encompassing the latest research and advancements in the field. By fully utilizing internet technology for manuscript submission and peer review, articles are published rapidly. Medicinal Chemistry is an essential journal for all those involved in drug design and discovery.

《Medicinal Chemistry》是一本经过同行评审的期刊，旨在涵盖药物化学和合理药物设计领域的最新杰出进展。该期刊发表原创研究、小型评论文章以及客座编辑的主题专刊，涉及该领域的最新研究和发展。通过充分利用互联网技术进行稿件提交和同行评审，文章得以快速发表。药物化学是所有参与药物设计和发现的研究人员的重要期刊。

Category	Quartile
医学	4
医学, 药物化学	4

Synthesis, Pharmacological Activities, Structure-activity Relationship of 1,3,4-Oxadiazole-Piperazine Conjugates: A Review

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Journal Info

Category	Quartile
CHEMISTRY, MEDICINAL	3