ABSTRACT Daily rhythms in the rate and specificity of protein synthesis occur in most mammalian cells through an interaction between cell‐autonomous circadian regulation and daily cycles of systemic cues. However, the overall protein content of a typical cell changes little over 24 h. For most proteins, translation appears to be coordinated with protein degradation, producing phases of proteomic renewal that maximize energy efficiency while broadly maintaining proteostasis across the solar cycle. We propose that a major function of this temporal compartmentalization—and of circadian rhythmicity in general—is to optimize the energy efficiency of protein synthesis and associated processes such as complex assembly. We further propose that much of this temporal compartmentalization is achieved at the level of translational initiation, such that the translational machinery alternates between distinct translational mechanisms, each using a distinct toolkit of phosphoproteins to preferentially recognize and translate different classes of mRNA.

Nathan R. James

John S. O'Neill

BioEssays

分子 - 细胞 - 生物医学 - 生理学 - 转化研究 - 系统 - 鼓励假设 BIOESSAYS 是一份经过同行评审、审查和讨论的期刊。我们的目标是在分子、遗传、细胞或生理维度上发表当代生物学的新颖见解、前瞻性评论和评论，并作为这些领域新思想的讨论论坛。另一个目标是鼓励在有机体研究、系统方法和生态系统方面的跨学科和综合生物学，在适当的情况下。

BioEssays is a peer-reviewed journal that focuses on molecular, cellular, biomedical, physiological, translational research, and systems biology. Our aim is to publish novel insights, forward-looking reviews, and comprehensive commentaries in contemporary biology, serving as a forum for discussion of new ideas in these fields. Additionally, we encourage interdisciplinary and integrative biology research in organism studies, systems approaches, and ecosystems where appropriate.

BioEssays 是一本经过同行评审的期刊，专注于分子、细胞、生物医学、生理学、转化研究和系统生物学等领域。我们的目标是发表当代生物学的新颖见解、前瞻性评论和综合评述，并为这些领域的新思想提供讨论平台。此外，我们还鼓励在有机体研究、系统方法和生态系统方面的跨学科和综合生物学研究。

Category	Quartile
生物学	3
生物学, 生物学	3
生物学, 生化与分子生物学	4

Circadian Control of Protein Synthesis

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