Sepsis-associated acute lung injury (SALI) is a common complication of sepsis, consisting of a dysfunctional host response to infection-mediated heterogenous complexes. SALI is reported in up to 50 % of patients with sepsis and causes poor outcomes. Despite high incidence, there is a lack of understanding in its pathogenesis and optimal treatment. A better understanding of the molecular mechanisms underlying SALI may help produce better therapeutics. The effects of altered cell-death mechanisms, such as non-apoptotic regulated cell death (RCD) (i.e., ferroptosis), on the development of SALI are beginning to be discovered, while targeting ferroptosis as a meaningful target in SALI is increasingly being recognized. Here, we outline how a susceptible lung alveoli may develop SALI. Then we discuss the general mechanisms underlying ferroptosis, and how it contributes to SALI. We then outline the chemical structures of the emerging agents or compounds that can protect against SALI by inhibiting ferroptosis, summarizing their potential pharmacological effects. Finally, we highlight key limitations and possible strategies to overcome them. This review suggests that a detailed mechanistic and biological understanding of ferroptosis can foster the development of pharmacological antagonists in the treatment of SALI.

Yu Wang

Weixue Wang

Yi Zhang

Joshua S Fleishman

Hongquan Wang

European Journal of Medicinal Chemistry

《欧洲药物化学杂志》是一本全球性期刊，发表关于药物化学各个方面的研究。它为发表原创论文提供了一个媒介，也欢迎评论性的论文。典型的论文将报告化合物的有机合成、表征和药理学评价。其他感兴趣的主题是药物设计、QSAR、分子建模、药物-受体相互作用、药物代谢的分子方面、前药合成和药物靶向。该杂志希望手稿能够展示研究的合理性，提供对化合物设计或机制理解的洞察力，或阐明目标。

The European Journal of Medicinal Chemistry is a global journal that focuses on various aspects of medicinal chemistry. It provides a platform for the publication of original research papers and also welcomes review articles. Typical research papers report on the organic synthesis, characterization, and pharmacological evaluation of compounds. Other relevant topics include drug design, quantitative structure-activity relationships (QSAR), molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis, and drug targeting. The journal encourages manuscripts that demonstrate the rationale of the research, provide insights into compound design or mechanistic understanding, or clarify the objectives of the study.

《欧洲药物化学杂志》是一本全球性的期刊，专注于药物化学的各个方面。它为原创研究论文提供了一个发表平台，同时也欢迎评论性论文。典型的研究论文通常会报告化合物的有机合成、表征及药理学评估。其他相关主题包括药物设计、定量构效关系（QSAR）、分子建模、药物与受体的相互作用、药物代谢的分子机制、前药合成以及药物靶向。该杂志希望手稿能够展示研究的合理性，提供对化合物设计或机制理解的深刻见解，或阐明研究目标。

Category	Quartile
医学	2
医学, 药物化学	1

Targeting ferroptosis offers therapy choice in sepsis-associated acute lung injury

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Journal Info

Category	Quartile
CHEMISTRY, MEDICINAL	1