The p53 protein has attracted huge research interest over several decades due to its role as one of the most important tumor suppressors in mammals, which orchestrates a synchronous response from normal cells in the body to various forms of stress. The diverse cellular activities of the p53 protein are regulated mainly via its post-translational modifications (PTMs). PTMs affect p53 on several levels: at the level of the assembly of tetrameric complexes on DNA to transactivate its target genes, at the level of the assembly of tetrameric complexes on DNA to transactivate its target genes; at the level of proteolysis in the absence of stress; and on the contrary, at the level of augmented protein stability in response to stress signals. Disruptions in these regulatory mechanisms can lead to deviations from normal cellular function, boosting tumor initiation and progression. Conversely, targeted interventions in these pathways could prove beneficial for the development of antitumor therapies. Advancing our understanding of p53 modifiers and the proteins involved in its regulation equips researchers with an expanded toolkit for studying cellular processes and for developing biologically active molecules that influence p53-mediated responses.

Tatiana A. Grigoreva

Angelina A. Romanova

Vyacheslav G. Tribulovich

Nikolay B. Pestov

Ruslan A. Oganov

Diana K. Kovaleva

Tatyana V. Korneenko

Nickolai A. Barlev

Pharmaceuticals

PHARMACEUTICALS (ISSN 1424-8247) 是药物化学和相关药物科学的国际科学期刊。

PHARMACEUTICALS is an international scientific journal that focuses on the field of pharmaceutical chemistry and related drug sciences, dedicated to publishing high-quality research findings.

《Pharmaceuticals》是一本国际科学期刊，专注于药物化学及相关药物科学领域，致力于发表高质量的研究成果。

Category	Quartile
医学	3
医学, 药物化学	3
医学, 药学	3

p53: The Multifaceted Roles of Covalent Modifications in Cancer

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	1