Many studies have explored different loading and rehabilitation strategies, yet rehabilitation intensity and its impact on the local strain environment and bone healing have largely not been investigated. This study combined implantable strain sensors and subject-specific finite element models in a 2 mm rodent segmental bone defect model. After injury animals were underwent high or low intensity rehabilitation. High intensity rehabilitation increased local strains within the regenerative niche by an average of 44% compared to the low intensity rehabilitation. Finite element modeling demonstrated that resistance rehabilitation significantly increased compressive strain by a factor of 2.0 at week 2 and 4.45 after 4 weeks of rehabilitation. Animals that underwent resistance running had the greatest bone volume and improved functional recovery with regenerated femurs that matched intact failure torque and torsional stiffness values. These results demonstrate the potential for early resistance rehabilitation to improve bone healing.

Kylie E. Williams

Julia Andraca Harrer

Steven A. LaBelle

Kelly Leguineche

Jarred Kaiser

Salil Karipott

Angela Lin

Alyssa Vongphachanh

Travis Fulton

J. Walker Rosenthal

Farhan Muhib

Keat Ghee Ong

Jeffrey A. Weiss

Nick J. Willett

Robert E. Guldberg

npj Regenerative Medicine

NPJ REGENERATIVE MEDICINE 是一本新的开放获取、仅限在线的期刊，致力于发表最高质量的研究，以帮助人体修复、替换、恢复和再生受损组织和器官。

NPJ Regenerative Medicine is a new open-access, online-only journal dedicated to publishing high-quality research aimed at facilitating the repair, replacement, restoration, and regeneration of damaged tissues and organs in the human body.

NPJ Regenerative Medicine 是一本新的开放获取、仅限在线的期刊，专注于发表高质量的研究，旨在促进人体对受损组织和器官的修复、替换、恢复和再生。

Early resistance rehabilitation improves functional regeneration following segmental bone defect injury

早期抗阻康复改善节段性骨缺损损伤后的功能再生

Category	Quartile
医学	1
医学, 工程生物医学	1
医学, 细胞与组织工程	2

Early resistance rehabilitation improves functional regeneration following segmental bone defect injury

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Journal Info

Category	Quartile
ENGINEERING, BIOMEDICAL	1