Catalytic asymmetric conjugate additions of carbon nucleophiles have emerged as a potent tool for constructing multi-stereogenic molecules with precise stereochemical control. This review explores the concept of diastereodivergence in such reactions, focusing on strategies to achieve selective access to diverse diastereomeric products upon carbon-carbon bond formation. Drawing from a rich array of examples, we delve into key approaches for controlling the stereochemical outcome of these transformations, including alteration of alkene geometry, fine-tuning of reaction parameters, synergistic catalysis, and isomerization of conjugate adducts. Additionally, we highlight the iterative strategies for conjugate additions, showcasing their potential for diastereodivergent synthesis of methyl-branched stereocenters in 1,3-relationships. By presenting a concentrated overview of this significant topic, this review aims to provide valuable insights into the design and execution of stereodivergent catalytic conjugate additions, offering new avenues for advancing stereoselective synthesis and structural diversity in organic synthesis.

Byungjun Kim

Hooseung Lee

Ilwoo Song

Sarah Yunmi Lee

Chemical Society Reviews

来自整个化学科学领域的高影响力评论之家。

Chemical Society Reviews is a high-impact review journal covering the entire field of chemical sciences, dedicated to providing the latest research findings and in-depth analyses.

《Chemical Society Reviews》是一个涵盖整个化学科学领域的高影响力评论期刊，致力于提供最新的研究成果和深入的分析。

Category	Quartile
化学	1
化学, 化学综合	1

Diastereodivergence in catalytic asymmetric conjugate addition of carbon nucleophiles

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Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	1