To investigate the effect of orthokeratology (ortho-k) treatment on choroidal thickness and its relationship with axial length change.Seventy-seven myopic subjects aged between 7 and 17 years were treated with ortho-k lenses (n = 39) or single-vision spectacle lenses (SVL, n = 38). Choroidal thickness and axial length measurements were taken at baseline and repeated 1 week and 3 weeks after lens wear for the ortho-k group and at 3 weeks for the SVL group. Parafoveal choroidal thickness was assessed using optical coherence tomography and segmented into nine regions according to the Early Treatment Diabetic Retinopathy Study (ETDRS) within a 6 × 6 mm circular zone centered on the fovea. Axial length was measured using partial coherence interferometry. The changes in subfoveal choroidal thickness were compared to the changes in axial length in both study groups.The change in axial length was significantly correlated with the change in choroidal thickness in both groups at 3 weeks (ortho-k, r = -0.351, p = 0.028 vs. SVL, r = -0.408, p = 0.011). Parafoveal choroidal thickness increased after 3 weeks of lens wear in the ortho-k group (mean, 21.8 ± 25.2 μm) but did not change in the SVL group (mean, 0.1 ± 19.7 μm). Choroidal thickness significantly varied across the posterior retinal regions (F = 82.14, p < 0.001), with the temporal regions being thickest and nasal regions being thinnest. After 3 weeks of ortho-k treatment, the magnitude of change (range, 14.1-27.6 μm) in choroidal thickness of the nine ETDRS regions was proportional to the baseline choroidal thickness in those regions (r = 0.88, p = 0.002). Axial length did not significantly change over time (F = 0.001, p = 0.975) and did not differ between the two treatment modalities (F = 0.305, p = 0.582).Choroidal thickness increases after short-term ortho-k treatment. Regional choroidal thickening after ortho-k treatment may be attributable to the altered retinal defocus profile associated with ortho-k lens wear.

Zhi Chen

Feng Xue

Jiaqi Zhou

Xiaomei Qu

Xingtao Zhou

Optometry and Vision Science

OPTOMETRY AND VISION SCIENCE 是美国验光学会的月度同行评审科学出版物，自 1924 年以来发表原创研究。 OPTOMETRY AND VISION SCIENCE 是国际公认的关于当前验光、生理光学、视觉科学发现的教育和信息来源，及相关领域。该杂志考虑了推动临床实践、视觉科学和公共卫生的原创性贡献。作者应该记住，该杂志的读者遍及全球，他们的投稿应该与广大读者相关并引起他们的兴趣。主题优先事项包括但不限于：临床和实验室研究、循证审查、隐形眼镜、眼球生长和屈光不正发展、眼球运动、视觉功能和感知、眼睛生物学和眼部疾病、流行病学和公共卫生，生物医学光学和仪器，新颖和重要的临床观察和治疗，以及验光教育。

Optometry and Vision Science is a monthly peer-reviewed scientific journal of the American Academy of Optometry, publishing original research since 1924. It is internationally recognized as a key source of education and information on current discoveries in optometry, physiological optics, and vision science, as well as related fields. The journal welcomes original contributions that advance clinical practice, vision science, and public health. Authors should keep in mind that the readership of the journal is global, and their submissions should be relevant and engaging to a wide audience. Priority topics include, but are not limited to: clinical and laboratory research, evidence-based reviews, contact lenses, ocular growth and refractive development, eye movements, visual function and perception, ocular biology and eye diseases, epidemiology and public health, biomedical optics and instrumentation, novel and significant clinical observations and treatments, and optometric education.

《Optometry and Vision Science》是美国验光学会的月度同行评审科学期刊，自1924年以来发表原创研究。该期刊被国际公认为关于当前验光、生理光学和视觉科学发现的重要教育和信息来源，涵盖相关领域。期刊欢迎推动临床实践、视觉科学和公共卫生的原创性贡献。作者应考虑到该期刊的读者遍布全球，因此投稿内容应与广大读者相关并引起他们的兴趣。主题优先事项包括但不限于：临床和实验室研究、循证审查、隐形眼镜、眼球生长和屈光不正发展、眼球运动、视觉功能和感知、眼睛生物学和眼部疾病、流行病学和公共卫生、生物医学光学和仪器、新颖和重要的临床观察和治疗，以及验光教育。

Optom Vis Sci

Effects of Orthokeratology on Choroidal Thickness and Axial Length

Choroidal thickness increases after short-term ortho-k treatment and may be attributable to the altered retinal defocus profile associated with orthi-k lens wear.

Category	Quartile
医学	4
医学, 眼科学	4

Effects of Orthokeratology on Choroidal Thickness and Axial Length

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