NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of modified chromatin decorated with bactericidal proteins from granules and cytoplasm. Various pathogens, antibodies and immune complexes, cytokines, microcrystals, and other physiological stimuli can cause NETosis. Induction of NETosis depends on reactive oxygen species (ROS), the main source of which is NADPH oxidase. Activation of NADPH oxidase depends on increase in the concentration of Ca2+ in the cytoplasm and in some cases on the generation of ROS in mitochondria. NETosis includes release of the granule components into the cytosol, modification of histones leading to chromatin decondensation, destruction of the nuclear envelope, as well as formation of pores in the plasma membrane. In this review, basic mechanisms of NETosis, as well as its role in the pathogenesis of some diseases including COVID-19 are discussed.

N. V. Vorobjeva

B. V. Chernyak

Biochemistry (Moscow)

BIOCHEMISTRY (MOSCOW) 是一本收录生物化学所有领域以及分子生物学、生物有机化学、微生物学、免疫学、生理学和生物医学科学的生化方面的研究论文的期刊。报道还延伸到生物化学的新实验方法、生化重要性的理论贡献、当代生化主题的评论和小型评论（生物化学新闻）。

Biochemistry (Moscow) is a journal that covers all areas of biochemistry, including research papers in molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. The journal also reports on new experimental methods in biochemistry, theoretical contributions of significant importance, and reviews and brief commentaries on contemporary biochemical topics (Biochemistry News).

《Biochemistry (Moscow)》是一本涵盖生物化学各个领域的期刊，涉及分子生物学、生物有机化学、微生物学、免疫学、生理学和生物医学科学的研究论文。期刊内容还包括生物化学的新实验方法、理论贡献以及当代生化主题的评论和简短综述（生物化学新闻）。

Biochemistry Moscow

NETosis: Molecular Mechanisms, Role in Physiology and Pathology

Basic mechanisms of NETosis, as well as its role in the pathogenesis of some diseases including COVID-19 are discussed.

Category	Quartile
生物学	4
生物学, 生化与分子生物学	4

NETosis: Molecular Mechanisms, Role in Physiology and Pathology

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