In this study, hollow mesoporous silica nanoparticles (HMSN) coated with a 4T1 tumor cell membrane were used to construct biomimetic nanomaterials (DTX@CHMSN) for the treatment of breast cancer. The nanodrug can improve the water solubility of polyenetaxel (DTX) by taking advantage of the special structure, good biocompatibility, and adjustable surface chemical properties of HMSN. Hollow mesoporous silica nanoparticles are coated with 4T1 cell membranes derived from homologous tumors (CHMSN). Adhesion glycoproteins on cancer cell membranes specifically bind to receptors on the cell membranes of the same cancer cell to target specific breast cancer tissues. At the same time, the cell membrane of the 4T1 tumor also contains CD47 protein, which can be specifically recognized by the immune system to produce immune escape. Therefore, the biomimetic nanomedicine DTX@CHMSN, with homologous targeting and immune escape ability, can accumulate in large quantities at the tumor site, reduce systemic toxicity, and thus improve the therapeutic effect.

Mengkang Liu

Yufeng Sun

Qiuxian Wei

Anna Zhang

SaiFei Wang

Dan Wang

Zhipeng Dong

Xiaonan Ma

Ran Yan

Yue Wang

ACS Medicinal Chemistry Letters

ACS 药物化学快报有兴趣接收讨论药物化学各个方面的手稿。该杂志将发表涉及广泛主题的研究，包括化合物设计和优化、生物评估、药物递送、显像剂以及大小生物活性分子的药理学。具体领域包括但不限于：先导生物活性分子和药物（小分子和生物制剂）的鉴定、合成和优化药物发现背景下新分子实体的生物学表征用于鉴定或鉴定的计算、化学信息学和结构研究生物活性分子、配体及其靶标等的 SAR 分析 新的和改进的方法，包括辐射生物化学，广泛应用于药物化学 合成和天然（植物和其他）来源的生物活性分子的发现技术 解决机制的药代动力学/药效学研究潜在的药物处置和反应用于增强药物设计和药物化学转化为临床的药物遗传学和药物基因组学研究机械药物代谢和代谢酶基因表达的调节与药物化学相关的化学专利LD。

ACS Medicinal Chemistry Letters welcomes submissions of manuscripts discussing various aspects of medicinal chemistry. The journal publishes research covering a wide range of topics, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and the pharmacology of both small and large bioactive molecules. Specific areas of interest include, but are not limited to: identification, synthesis, and optimization of lead bioactive molecules and drugs (small molecules and biologics); biological characterization of new molecular entities in the context of drug discovery; computational, cheminformatics, and structural studies for identification or confirmation; SAR analysis of bioactive molecules, ligands, and their targets; novel and improved methods, including radiobiochemistry, widely applied in medicinal chemistry; discovery techniques for bioactive molecules from synthetic and natural (plant and other) sources; mechanistic pharmacokinetic/pharmacodynamic studies; potential drug disposition and reactions aimed at enhancing drug design; and pharmacogenetics and pharmacogenomics research related to the translation of medicinal chemistry into clinical applications, including mechanistic drug metabolism and regulation of gene expression of metabolic enzymes.

ACS 药物化学快报欢迎提交关于药物化学各个方面的手稿。该杂志将发表涉及广泛主题的研究，包括化合物的设计与优化、生物评估、药物递送、显像剂以及大分子和小分子药物的药理学。具体领域包括但不限于：先导生物活性分子和药物（小分子和生物制剂）的鉴定、合成和优化；在药物发现背景下新分子实体的生物学表征；用于鉴定或确认的计算、化学信息学和结构研究；生物活性分子、配体及其靶标的SAR分析；新的和改进的方法，包括辐射生物化学，广泛应用于药物化学；合成和天然（植物及其他）来源的生物活性分子的发现技术；解决机制的药代动力学/药效学研究；潜在的药物处置和反应，用于增强药物设计；以及药物化学转化为临床的药物遗传学和药物基因组学研究，机械药物代谢和代谢酶基因表达的调节与药物化学相关的化学专利。

Category	Quartile
医学	3
医学, 药物化学	3

4T1 Cell Membrane Biomimetic Nanovehicle for Enhanced Breast Cancer Treatment

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Category	Quartile
CHEMISTRY, MEDICINAL	2