Abstract The synthesis of aryl amines via the formation of a C−N bond is an essential tool for the preparation of functional materials, active pharmaceutical ingredients and bioactive products. Usually, this chemical connection is only possible by transition metal‐catalyzed reactions, photochemistry or electrochemistry. Here, we report a metal‐free arene C−H amination using hydroxylamine derivatives under benign conditions. A charge transfer interaction between the aminating reagents TsONHR and the arene substrates enables the chemoselective amination of the arene, even in the presence of various functional groups. Oxygen was crucial for an effective conversion and its accelerating role for the electron transfer step was proven experimentally. In addition, this was rationalized by a theoretical study which indicated the involvement of a dioxygen‐bridged complex with a “Sandwich‐like” arrangement of the aromatic starting materials and the aminating agents at the dioxygen molecule. magnified image

Tao Wang

Marvin Hoffmann

Andreas Dreuw

Edina Hasagić

Chao Hu

Philipp M. Stein

Sina Witzel

Hongwei Shi

Yangyang Yang

Matthias Rudolph

Fabian Stuck

Frank Rominger

Marion Kerscher

Peter Comba

A. Stephen K. Hashmi

Advanced Synthesis & Catalysis

Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.

The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.

Advanced Synthesis and Catalysis (ASC) is the leading journal in the fields of organic, organometallic, and applied chemistry. The high impact of ASC is attributed to its unique focus on publishing exciting new results from both academic and industrial laboratories regarding efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies for achieving green synthesis, ASC also features significant contributions towards this goal through synthesis design, reaction techniques, flow chemistry, continuous processing, multiphase catalysis, green solvents, catalyst immobilization and recycling, separation science, and process development. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.

《Advanced Synthesis and Catalysis》是有机化学、金属有机化学和应用化学领域的领先期刊。该期刊的高影响力源于其独特的关注点，主要发表来自学术界和工业界的关于高效、实用和环保的有机合成的新成果。虽然均相催化、非均相催化、有机催化和酶催化是实现绿色合成的关键技术，但《Advanced Synthesis and Catalysis》也刊登了在合成设计、反应技术、流动化学和连续处理、多相催化、绿色溶剂、催化剂固定化与回收、分离科学和工艺开发等方面对实现同一目标的重要贡献。期刊的目标和范围可以在作者通知或每期目录的首页找到。

Advanced Synthesis and Catalysis

A Metal‐Free Direct Arene C−H Amination

无金属直接芳烃C−H胺化

Category	Quartile
化学	2
化学, 应用化学	2
化学, 有机化学	2

A Metal‐Free Direct Arene C−H Amination

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Journal Info

Category	Quartile
CHEMISTRY, ORGANIC	1