Abstract Malaria, caused by the genus Plasmodium , remains a global public health concern. It is estimated by the World Health Organization that over 40% of the world's population lives in areas at risk for malarial transmission, and around half a million people succumb to this infectious disease annually, which is related to the rapid spread of drug‐resistant parasite strains. Indole derivatives, which possess broad‐spectrum pharmacological properties, play a crucial role in the discovery of new drugs. Many indole derivatives exhibited potential in vitro and in vivo activity against both drug‐sensitive and drug‐resistant malaria, suggesting that the indole moiety is a useful template for the development of novel antimalarial agents. This review outlines the advances in indole alkaloids and hybrids with antimalarial potential in the recent decade.

Jue‐Ying Li

Xiao‐Feng Sun

Jing‐Jing Li

Fen Yu

Yi Zhang

Xiu‐Juan Huang

Feng‐Xia Jiang

Archiv der Pharmazie

ARCHIV DER PHARMAZIE - CHEMISTRY IN LIFE SCIENCES 是一份致力于药物和药物化学各个领域研究和开发的国际期刊。重点放在将合成有机化学、结构生物学、分子建模、生物有机化学、天然产物化学、生物化学或分析方法与生物活性等药物或医学方面相结合的论文。该期刊的重点是原创研究论文，但也欢迎其他具有科学价值的贡献（例如评论、小型评论、亮点、专题讨论会贡献、讨论和论文）。

ARCHIV DER PHARMAZIE - CHEMISTRY IN LIFE SCIENCES is an international journal dedicated to research and development in all areas of pharmaceuticals and pharmaceutical chemistry. The focus is on papers that integrate synthetic organic chemistry, structural biology, molecular modeling, bioorganic chemistry, natural product chemistry, biochemistry, or analytical methods with bioactivity related to drugs or medicine. The journal primarily publishes original research articles but also welcomes other scientifically valuable contributions, such as reviews, mini-reviews, highlights, contributions to special discussions, discussions, and papers.

《ARCHIV DER PHARMAZIE - CHEMISTRY IN LIFE SCIENCES》是一份国际期刊，专注于药物和药物化学的各个研究领域。期刊的重点在于将合成有机化学、结构生物学、分子建模、生物有机化学、天然产物化学、生物化学及分析方法与药物或医学相关的生物活性相结合。该期刊主要发表原创研究论文，同时也欢迎其他具有科学价值的贡献，如评论、小型评论、亮点、专题讨论会贡献、讨论和论文。

The antimalarial activity of indole alkaloids and hybrids

This review outlines the advances in indole alkaloids and hybrids with antimalarial potential in the recent decade, suggesting that the indole moiety is a useful template for the development of novel antimalaria agents.

Category	Quartile
医学	3
医学, 化学综合	2
医学, 药学	2
医学, 药物化学	3

The antimalarial activity of indole alkaloids and hybrids

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	1