Vascular, fibrous/myofibroblastic, and myogenic tumors account for the majority of mesenchymal tumors in children. These tumors often show significant overlap in morphology and immunophenotype posing diagnostic difficulties and, thus, their classification remains challenging. Recent advances in immunohistochemistry have proved helpful in identifying a specific line of differentiation in some tumors, but other tumors remain difficult to classify. Molecular investigations have provided an existing tool to better understand the pathogenesis of some of these tumors and, in some cases like the EWING family of tumors, expanded the classification resulting in the emergence of previously unknown tumors. Some of these tumors are currently diagnosed according to their underlying molecular abnormality, such as CIC -rearranged sarcoma, BCOR -rearranged sarcoma, etc. This review focuses on the common mesenchymal neoplasms of the pediatric population with emphasis on the salient histologic features, immunoprofile, and molecular characteristics. For practical purposes, the latter are summarized in Supplemental Table 1, Supplemental Digital Content 1, http://links.lww.com/PAP/A46.

Omar Aljuboori

Ali G. Saad

Advances in Anatomic Pathology

ADVANCES IN ANATOMIC PATHOLOGY 提供了对解剖学和外科病理学关键发展的有针对性的报道。它涵盖了从基本形态到最先进的分子生物学技术的主题。该杂志从最近的世界文献中选择并有效地传达最重要的信息，并为管理日益增长的病理学信息流提供宝贵的帮助。

Advances in Anatomic Pathology offers targeted reporting on key developments in anatomic and surgical pathology. It covers a wide range of topics, from fundamental morphology to cutting-edge molecular biology techniques. The journal selects and effectively communicates the most important information from recent global literature, providing valuable assistance in managing the ever-growing flow of pathology information.

《Advances in Anatomic Pathology》提供了对解剖学和外科病理学关键发展的深入报道。该杂志涵盖从基本形态学到最先进的分子生物学技术的各个主题。它从最新的全球文献中筛选出最重要的信息，并有效地传达给读者，为管理日益增长的病理学信息流提供了宝贵的支持。

Category	Quartile
医学	2
医学, 病理学	2

Pediatric Mesenchymal Tumors

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