Editorial FocusNavigating the Extravascular Lung Waters of Pulmonary Edema in COVID-19 ARDSPranav Jain, MD, PhDGeorgios D. KitsiosMDPranav Jain1- Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, PAMD, PhD and Georgios D. KitsiosCorresponding author: Georgios D. Kitsios, MD, PhD, Assistant Professor of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh Medical Center, Address: UPMC Montefiore Hospital, NW628, 3459 Fifth Avenue, Pittsburgh, PA 15213, Email: kitsiosg@upmc.edu1- Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA2- Acute Lung Injury and Infection Center of Excellence, University of Pittsburgh, Pittsburgh, PA.3- Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PAMDPublished Online:11 Dec 2024https://doi.org/10.1152/ajplung.00383.2024MoreFiguresReferencesRelatedInformationPDF (168 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookXLinkedInWeChat We recommendMeasurement of extravascular lung water in patients with pulmonary edema.Michael A Matthay, American Journal of Physiology - Lung Cellular and Molecular Physiology, 2008Regional extravascular density of the lung in patients with acute pulmonary edemaP. Wollmer, Journal of Applied Physiology, 1987Reappraisal of extravascular lung thermal volume as a measure of pulmonary edemaW. H. Noble, Journal of Applied Physiology, 1980Effect of edema and hemodynamic changes on extravascular thermal volume of the lungB. A. Gray, Journal of Applied Physiology, 1984Pulmonary edema fluid movement within the lung.H O'Brodovich, American Journal of Physiology - Lung Cellular and Molecular Physiology, 2001First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial Brought to you by Pfizer Medical AffairsManaging patients with psoriatic arthritis? Learn about a potential treatment option for your patients with psoriatic arthritis & resources to help them get startedManaging the Challenge: A Guide to Systemic Treatments for Moderate to Severe Plaque Psoriasis Clinical Case ChallengeExploring Fatigue Roots in Psoriasis, Psoriatic Arthritis Learn MoreIdentifying Fatigue Factors in Psoriasis, Psoriatic Arthritis Discover MorePowered by Privacy policyGoogle Analytics settings Previous Back to Top Next Download PDF FiguresReferencesRelatedInformationSee PDF More from this issue > Articles in PressPublished 11 Dec 2024 Crossmark Copyright & PermissionsCopyright © 2025 the American Physiological Societyhttps://doi.org/10.1152/ajplung.00383.2024PubMed39659226History Received 25 November 2024 Accepted 28 November 2024 Published online 11 December 2024 Metrics We recommendMeasurement of extravascular lung water in patients with pulmonary edema.Michael A Matthay, American Journal of Physiology - Lung Cellular and Molecular Physiology, 2008Regional extravascular density of the lung in patients with acute pulmonary edemaP. Wollmer, Journal of Applied Physiology, 1987Reappraisal of extravascular lung thermal volume as a measure of pulmonary edemaW. H. Noble, Journal of Applied Physiology, 1980Effect of edema and hemodynamic changes on extravascular thermal volume of the lungB. A. Gray, Journal of Applied Physiology, 1984Pulmonary edema fluid movement within the lung.H O'Brodovich, American Journal of Physiology - Lung Cellular and Molecular Physiology, 2001First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial Brought to you by Pfizer Medical AffairsManaging patients with psoriatic arthritis? Learn about a potential treatment option for your patients with psoriatic arthritis & resources to help them get startedManaging the Challenge: A Guide to Systemic Treatments for Moderate to Severe Plaque Psoriasis Clinical Case ChallengeExploring Fatigue Roots in Psoriasis, Psoriatic Arthritis Learn MoreIdentifying Fatigue Factors in Psoriasis, Psoriatic Arthritis Discover MorePowered by Privacy policyGoogle Analytics settings publications0supporting0mentioning0contrasting0Smart Citations0000Citing PublicationsSupportingMentioningContrastingView CitationsSee how this article has been cited at scite.aiscite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Pranav Jain

Georgios D. Kitsios

AJP Lung Cellular and Molecular Physiology

美国生理学杂志-肺细胞和分子生理学发表原创研究，涵盖细胞和呼吸系统成分的正常和异常功能的分子、细胞和综合方面的广泛范围。感兴趣的领域包括导气道、肺循环、肺内皮细胞和上皮细胞、胸膜、肺中的神经内分泌和免疫细胞、参与控制呼吸的神经细胞以及膈肌和胸肌细胞。该杂志将涵盖的过程包括气体交换、细胞水平的代谢控制、细胞内信号传导、基因表达、基因组学、大分子及其周转、细胞-细胞和细胞-基质相互作用、细胞运动、分泌机制、膜功能、表面活性剂、基质成分、粘液和衬里材料、肺防御、巨噬细胞功能、盐、水和蛋白质的运输、呼吸系统的发育和分化，以及对环境的反应。

The American Journal of Physiology - Lung Cellular and Molecular Physiology publishes original research covering a wide range of molecular, cellular, and integrative aspects of normal and abnormal functions of cells and components of the respiratory system. Areas of interest include the airways, pulmonary circulation, pulmonary endothelial and epithelial cells, pleura, neuroendocrine and immune cells in the lung, neurons involved in the control of breathing, as well as diaphragm and chest muscle cells. The journal encompasses processes such as gas exchange, metabolic control at the cellular level, intracellular signaling, gene expression, genomics, macromolecule turnover, cell-cell and cell-matrix interactions, cell motility, secretory mechanisms, membrane function, surfactants, matrix components, mucus and lining materials, lung defense, macrophage function, transport of salts, water, and proteins, development and differentiation of the respiratory system, and responses to environmental challenges.

《American Journal of Physiology - Lung Cellular and Molecular Physiology》发表原创研究，涵盖细胞和呼吸系统成分的正常与异常功能的分子、细胞及综合方面的广泛内容。研究领域包括气道、肺循环、肺内皮细胞和上皮细胞、胸膜、肺中的神经内分泌和免疫细胞、参与控制呼吸的神经细胞，以及膈肌和胸肌细胞。该杂志涉及的过程包括气体交换、细胞代谢控制、细胞内信号传导、基因表达、基因组学、大分子及其周转、细胞间和细胞-基质相互作用、细胞运动、分泌机制、膜功能、表面活性剂、基质成分、粘液和衬里材料、肺防御、巨噬细胞功能、盐、水和蛋白质的运输、呼吸系统的发育与分化，以及对环境的反应。

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Navigating the Extravascular Lung Waters of Pulmonary Edema in COVID-19 ARDS

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