The tracer-to-infant deuterium dilution method for the measurement of milk intake was evaluated in twenty breast-fed and twenty formula-fed infants. The isotope method was compared with conventional direct-weighing techniques. Human milk intake was assessed by 5 d test-weighing. Intakes of formula, supplemental foods, and water were determined by pre- and post-weighing of feeding bottles. An oral dose of 200 mg 2 H 2 O/kg body-weight was given to each infant, and urine was sampled daily for 14 d. 2 H enrichment of the urine was measured by gas-isotope-ratio mass spectrometry. Milk intakes estimated from the deuterium dilution method were consistently higher than those from direct-weighing; the mean difference between methods was 106 (sd 47) g/d or 14% for the breast-fed group and 70 (sd 155) g/d or 8 % for the formula-fed group. Estimates of intake for some infants varied substantially between the two methods of measurement. When the estimated values of human milk intake were corrected for environmental water influx and insensible water loss during breast-feeding, the relative bias decreased to 5%. Correction of the estimated values of formula intake for environmental water influx decreased the relative bias to 1–2%. The acceptability of the deuterium dilution method to determine milk intake depends on the goals and the tolerance for error in group and individual intake estimates of a given study

Nancy F. Butte

William W. Wong

Peter D. Klein

Cutberto Garza

British Journal Of Nutrition

BRITISH JOURNAL OF NUTRITION 是一本领先的国际同行评审期刊，涵盖人类和临床营养、动物营养和营养学基础科学的研究。该杂志承认营养科学的多学科性质，包括来自营养研究的所有专业的材料，包括分子和细胞生物学以及营养基因组学。

The British Journal of Nutrition is a leading international peer-reviewed journal that focuses on research in human and clinical nutrition, animal nutrition, and the fundamental sciences of nutrition. The journal recognizes the multidisciplinary nature of nutritional science, encompassing materials from all specialties within nutritional research, including molecular and cellular biology as well as nutritional genomics.

《British Journal of Nutrition》是一本国际领先的同行评审期刊，专注于人类和临床营养、动物营养以及营养学基础科学的研究。该期刊承认营养科学的多学科特性，涵盖来自营养研究各个领域的研究成果，包括分子和细胞生物学以及营养基因组学。

British Journal of Nutrition

Measurement of milk intake: tracer-to-infant deuterium dilution method

Estimates of intake for some infants varied substantially between the two methods of measurement, and the acceptability of the deuterium dilution method to determine milk intake depends on the goals and the tolerance for error in group and individual intake estimates of a given study.

Category	Quartile
医学	3
医学, 营养学	3

Measurement of milk intake: tracer-to-infant deuterium dilution method

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