Hemophagocytic lymphohistiocytosis (HLH) is a frequently fatal and likely underdiagnosed disease involving a final common pathway of hypercytokinemia, which can result in end-organ damage and death. Although an early diagnosis is crucial to decrease mortality, the definitive diagnosis is often challenging because of the lack of specificity of currently accepted diagnostic criteria and the absence of confirmatory gold standards. Because of the wide range of laboratory assays involved in the diagnosis of HLH, practicing pathologists from a broad spectrum of clinical specialties need to be aware of the disease so that they may appropriately flag results and convey them to their clinical counterparts. Our article summarizes these new advances in the diagnosis of HLH and includes a review of clinical findings, updated understanding of the pathogenesis, and promising new testing methods.

Flavia G. N. Rosado

Annette S. Kim

American Journal of Clinical Pathology

美国临床病理学杂志 (AJCP) 是美国临床病理学会和临床实验室医师和科学家学会的官方期刊。它是出版有关人类疾病的新型解剖病理学和实验室医学观察文章的领先国际期刊。 AJCP 强调的文章侧重于将不断发展的技术应用于疾病和状况的诊断和表征，以及与改善患者护理有直接联系的文章。

The American Journal of Clinical Pathology is the official journal of the American Society for Clinical Pathology and the Society of Clinical Laboratory Scientists. It is a leading international journal that publishes innovative articles on anatomic pathology and laboratory medicine observations related to human diseases. The journal emphasizes articles that focus on the application of evolving technologies in the diagnosis and characterization of diseases and conditions, as well as those that are directly linked to improving patient care.

《American Journal of Clinical Pathology》是美国临床病理学会和临床实验室医师与科学家学会的官方期刊。该期刊是国际领先的出版有关人类疾病的解剖病理学和实验室医学观察文章的期刊。它强调的文章主要集中在将不断发展的技术应用于疾病和病症的诊断与表征，以及与改善患者护理直接相关的研究。

Hemophagocytic Lymphohistiocytosis

This article summarizes new advances in the diagnosis of HLH and includes a review of clinical findings, updated understanding of the pathogenesis, and promising new testing methods.

Category	Quartile
医学	4
医学, 病理学	3

Hemophagocytic Lymphohistiocytosis

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