Intrauterine adhesion (IUA) can negatively impact on pregnancy outcomes, leading to reduced pregnancy rates, secondary infertility, and an increased risk of pregnancy complications. Studies have shown that the application of platelet-rich plasma (PRP) in IUA patients is effective. However, the clinical readhesive rate of IUA after treatment is still high, especially in severe cases. Platelet-rich plasma double-network hydrogel (DN gel) is an engineered PRP double network hydrogel, which is a sodium alginate (SA) based PRP hydrogel with egg carton ion cross-linking and fibrin double network. The results of this study show that intrauterine injection of DN gel has a better effect on promoting endometrial regeneration and enhancing endometrial receptivity than PRP gel. The mechanism is analyzed through single-cell sequencing, which may be achieved by increasing the expression of neutrophils (Neut), natural killer cells (NK), and type I classical dendritic cells (cDC1) in the endometrium and inhibiting the infiltration of M2 macrophages. Overall, based on the good healing efficiency and good biocompatibility of DN gel, it is expected to become a method of treating IUA with better efficacy and faster clinical translation.

Zhuomin Wang

Ying Gu

Yiyuan Qu

Xujia Huang

Tao Sun

Wei Wu

Qianyu Hu

Xiao Chen

Yu Li

Huafei Zhao

Yingying Hu

Bingbing Wu

Jian Xu

Advanced Biology

Prevention of Intrauterine Adhesion with Platelet‐Rich Plasma Double‐Network Hydrogel

富血小板血浆双网络水凝胶预防宫腔粘连

Category	Quartile
生物学	3
生物学, 材料科学生物材料	4

Prevention of Intrauterine Adhesion with Platelet‐Rich Plasma Double‐Network Hydrogel

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Journal Info

Category	Quartile
MATERIALS SCIENCE, BIOMATERIALS	3