Chronic sleep deprivation may be required to reveal the most serious physiological consequences of sleep loss, but it usually requires strong stimulation which can obscure the interpretation of effects. The disk-over-water method permits chronic sleep deprivation of rats with gentle physical stimulation that can be equally applied to yoked control rats. A series of studies with this method has revealed little or no pathology in the control rats. The deprived rats show a reliable syndrome that includes temperature changes (which vary with the sleep stages that are lost); heat seeking behavior; increased food intake; weight loss; increased metabolic rate; increased plasma norepinephrine; decreased plasma thyroxine; an increased triiodothyronine-thyroxine ratio; and an increase of an enzyme which mediates thermogenesis by brown adipose tissue. The temperature changes are attributable to excessive heat loss and an elevated thermoregulatory setpoint, both of which increase thermoregulatory load, and the other changes are interpretable as responses to this increased load. This pattern indicates that sleep serves a thermoregulatory function in the rat. The sleep deprived rats also show stereotypic ulcerative and hyperkeratotic lesions localized to the tail and plantar surfaces of the paws, and they die within a matter of weeks; the mediation of these changes is unresolved.

A Rechtschaffen

B M Bergmann

Behavioural brain research

BEHAVIORAL BRAIN RESEARCH 是一份国际性的跨学科期刊，致力于发表广泛定义的行为神经科学领域的文章。只要目标是描述行为背后的神经机制，来自包括神经科学、行为科学或认知科学的整个学科范围的贡献都是合适的。因此，研究的范围可以从对脑行为关系的神经生理学、神经解剖学、神经化学或神经药理学分析，包括使用分子遗传学或行为遗传学方法，到涉及使用脑成像技术的研究，再到神经行为学研究。鼓励原创研究、主要方法学进展或新颖概念方法的报告。该杂志还将考虑对选定主题的批评性评论。

Behavioural Brain Research is an international interdisciplinary journal dedicated to publishing articles in the broadly defined field of behavioral neuroscience. Contributions from a wide range of disciplines, including neuroscience, behavioral science, and cognitive science, are welcome as long as the aim is to describe the neural mechanisms underlying behavior. Thus, the scope of research can range from neurophysiological, neuroanatomical, neurochemical, or neuropharmacological analyses of the brain-behavior relationship, including studies using molecular genetics or behavioral genetics methods, to research involving brain imaging techniques, and to studies in neurobehavior. We encourage reports of original research, significant methodological advancements, or novel conceptual approaches. The journal also considers critical reviews on selected topics.

《Behavioural Brain Research》是一本国际跨学科期刊，专注于发表行为神经科学领域的研究文章。只要研究目标是描述行为背后的神经机制，来自神经科学、行为科学或认知科学等各个学科的贡献都是适合的。因此，研究范围可以包括对脑与行为关系的神经生理学、神经解剖学、神经化学或神经药理学的分析，使用分子遗传学或行为遗传学方法的研究，应用脑成像技术的研究，以及神经行为学的研究。我们鼓励原创研究、主要方法学进展或新颖概念的报告。此外，该期刊也欢迎对特定主题的批评性评论。

Behavioural Brain Research

Behav Brain Res

Sleep deprivation in the rat by the disk-over-water method.

The disk-over-water method permits chronic sleep deprivation of rats with gentle physical stimulation that can be equally applied to yoked control rats, and a series of studies with this method has revealed little or no pathology in the control rats.

Category	Quartile
心理学	3
心理学, 行为科学	4
心理学, 神经科学	4

Sleep deprivation in the rat by the disk-over-water method.

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